MMP-3 Contributes to Nigrostriatal Dopaminergic Neuronal Loss, BBB Damage, and Neuroinflammation in an MPTP Mouse Model of Parkinson’s Disease

Joint Authors

Yune, Tae Young
Kim, Yoon-Seong
Maeng, Sungho
Bok, Eugene
Jin, Byung Kwan
Chung, Young Cheul

Source

Mediators of Inflammation

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-06-19

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Diseases

Abstract EN

The present study examined whether matrix metalloproteinase-3 (MMP-3) participates in the loss of dopaminergic (DA) neurons in the nigrostriatal pathway in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease with blood brain barrier (BBB) damage and infiltration of peripheral immune cells.

Tyrosine hydroxylase (TH) immunostaining of brain sections from MPTP-treated mice showed that MPTP induced significant degeneration of nigrostriatal DA neurons.

Moreover, FITC-labeled albumin detection and immunostaining revealed that MPTP caused damage to the BBB and increased the number of ED-1- and CD-3-immunopositive cells in the substantia nigra (SN).

Genetic ablation of MMP-3 reduced the nigrostriatal DA neuron loss and improved motor function.

This neuroprotective effect afforded by MMP-3 deletion was associated with the suppression of BBB disruption and a decrease in the number of ED-1- and CD-3-immunopositive cells in the SN.

These data suggest that MMP-3 could play a crucial role in neurodegenerative diseases such as PD in which BBB damage and neuroinflammation are implicated.

American Psychological Association (APA)

Chung, Young Cheul& Kim, Yoon-Seong& Bok, Eugene& Yune, Tae Young& Maeng, Sungho& Jin, Byung Kwan. 2013. MMP-3 Contributes to Nigrostriatal Dopaminergic Neuronal Loss, BBB Damage, and Neuroinflammation in an MPTP Mouse Model of Parkinson’s Disease. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-466664

Modern Language Association (MLA)

Chung, Young Cheul…[et al.]. MMP-3 Contributes to Nigrostriatal Dopaminergic Neuronal Loss, BBB Damage, and Neuroinflammation in an MPTP Mouse Model of Parkinson’s Disease. Mediators of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-466664

American Medical Association (AMA)

Chung, Young Cheul& Kim, Yoon-Seong& Bok, Eugene& Yune, Tae Young& Maeng, Sungho& Jin, Byung Kwan. MMP-3 Contributes to Nigrostriatal Dopaminergic Neuronal Loss, BBB Damage, and Neuroinflammation in an MPTP Mouse Model of Parkinson’s Disease. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-466664

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-466664