Oxidative Stress and Mitochondrial Dysfunction in Down’s Syndrome : Relevance to Aging and Dementia
Joint Authors
Coskun, Pinar E.
Busciglio, Jorge
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Genome-wide gene deregulation and oxidative stress appear to be critical factors determining the high variability of phenotypes in Down’s syndrome (DS).
Even though individuals with trisomy 21 exhibit a higher survival rate compared to other aneuploidies, most of them die in utero or early during postnatal life.
While the survivors are currently predicted to live past 60 years, they suffer higher incidence of age-related conditions including Alzheimer’s disease (AD).
This paper is centered on the mechanisms by which mitochondrial factors and oxidative stress may orchestrate an adaptive response directed to maintain basic cellular functions and survival in DS.
In this context, the timing of therapeutic interventions should be carefully considered for the successful treatment of chronic disorders in the DS population.
American Psychological Association (APA)
Coskun, Pinar E.& Busciglio, Jorge. 2012. Oxidative Stress and Mitochondrial Dysfunction in Down’s Syndrome : Relevance to Aging and Dementia. Current Gerontology and Geriatrics Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-467750
Modern Language Association (MLA)
Coskun, Pinar E.& Busciglio, Jorge. Oxidative Stress and Mitochondrial Dysfunction in Down’s Syndrome : Relevance to Aging and Dementia. Current Gerontology and Geriatrics Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-467750
American Medical Association (AMA)
Coskun, Pinar E.& Busciglio, Jorge. Oxidative Stress and Mitochondrial Dysfunction in Down’s Syndrome : Relevance to Aging and Dementia. Current Gerontology and Geriatrics Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-467750
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467750