Chinese Medicine Formula “Jian-Pi-Zhi-Dong Decoction” Attenuates Tourette Syndrome via Downregulating the Expression of Dopamine Transporter in Mice
Joint Authors
Wang, Dao-han
Zhang, Jin-ming
Liu, Xiao-fang
Wang, Su-mei
Li, Wei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Jian-Pi-Zhi-Dong Decoction (JPZDD) is dedicated to the treatment for Tourette syndrome (TS) with the guidance of the theories of Traditional Chinese Medicine (TCM).
This study aims to investigate the expression of dopamine transporter (DAT) in the striatum and stereotyped behavior of TS mice model by intervention of JPZDD.
Mice were induced by 3,3′-iminodipropionitrile (IDPN, 350 mg kg−1 day−1, i.p.) for 7 days and divided into 4 groups (n=20, each): control and IDPN groups were gavaged with saline and the remaining 2 groups with Tiapride (Tia, 50 mg kg−1 day−1) and JPZDD (20 g kg−1 day−1), respectively.
The results showed that the scores of stereotyped behavior in IDPN+JPZDD group were significantly reduced.
A noticeably increased 11C-β-CFT binding at bilateral striatum was observed after administration of JPZDD versus that of IDPN or Tia.
Immunohistochemistry and in situ hybridization studies manifested higher levels of DAT protein and mRNA in IDPN+JPZDD group.
These findings not only demonstrated that JPZDD could effectively inhibit the abnormal behaviors of TS mice model, but also increase the level of DAT in striatum.
Therefore, JPZDD could be one of potential treatments of patients with TS.
American Psychological Association (APA)
Wang, Dao-han& Li, Wei& Liu, Xiao-fang& Zhang, Jin-ming& Wang, Su-mei. 2013. Chinese Medicine Formula “Jian-Pi-Zhi-Dong Decoction” Attenuates Tourette Syndrome via Downregulating the Expression of Dopamine Transporter in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-467949
Modern Language Association (MLA)
Wang, Dao-han…[et al.]. Chinese Medicine Formula “Jian-Pi-Zhi-Dong Decoction” Attenuates Tourette Syndrome via Downregulating the Expression of Dopamine Transporter in Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-467949
American Medical Association (AMA)
Wang, Dao-han& Li, Wei& Liu, Xiao-fang& Zhang, Jin-ming& Wang, Su-mei. Chinese Medicine Formula “Jian-Pi-Zhi-Dong Decoction” Attenuates Tourette Syndrome via Downregulating the Expression of Dopamine Transporter in Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-467949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467949