A New Ratio for Protocol Categorization

Abstract EN

The present review describes and validates a new ratio “S” created for matching predictability and balance between TP and TN.

Validity of S was studied in a three-step process as follows: (i) S was applied to the data of a past study predicting cardiac output response to fluid bolus from response to passive leg raise (PLR); (ii) S was comparatively analyzed with traditional ratios by modeling different 2 * 2 contingency tables in 1000 hypothetical patients; (iii) precision of S was compared with other ratios by computing random fluctuations in the same patients.

In comparison to other ratios, S performs better in predicting the cardiac response to fluid bolus and supports more directly the clinical conclusions.

When the proportion of false responses is high, S is close to the coefficient correlation (CC).

When the proportion of true responses is high, S is the unique ratio that identifies the categorization that balances the proportion of TP and TN.

The precision of S is close to that of CC.

In conclusion, S should be considered for creating categories from quantitative variables; especially when matching predictability with balance between TP and TN is a concern.