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The Loss of HIF1α Leads to Increased Susceptibility to Cadmium-Chloride-Induced Toxicity in Mouse Embryonic Fibroblasts
Joint Authors
Grier, Elizabeth
Vengellur, Ajith
LaPres, John J.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-17
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Wild-type and HIF1α −/− MEF cells were used to determine the role of HIF1α in cadmium-induced toxicity.
Cadmium treatment did not affect HIF1-mediated transcription but led to caspase activation and apoptotic cell death in wild-type and HIF1α −/− cells.
Cadmium-induced cell death, however, was significantly higher in HIF1α −/− cells as compared to their wild-type counterparts.
Increased cell death in the HIF1α −/− cells was correlated with lower metallothionein protein, elevated levels of reactive oxygen species, and decreased superoxide dismutase enzyme activity.
The total and oxidized glutathione levels, and, correspondingly, lipid peroxidation levels were elevated in the null cells compared to wild-type cells, indicating increased antioxidant demand and greater oxidative stress.
Overall, the results suggest that basal levels of HIF1α play a protective role against cadmium-induced cytotoxicity in mouse embryonic fibroblasts by maintaining metallothionein and antioxidant activity levels.
American Psychological Association (APA)
Vengellur, Ajith& Grier, Elizabeth& LaPres, John J.. 2011. The Loss of HIF1α Leads to Increased Susceptibility to Cadmium-Chloride-Induced Toxicity in Mouse Embryonic Fibroblasts. Journal of Toxicology،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-468392
Modern Language Association (MLA)
Vengellur, Ajith…[et al.]. The Loss of HIF1α Leads to Increased Susceptibility to Cadmium-Chloride-Induced Toxicity in Mouse Embryonic Fibroblasts. Journal of Toxicology No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-468392
American Medical Association (AMA)
Vengellur, Ajith& Grier, Elizabeth& LaPres, John J.. The Loss of HIF1α Leads to Increased Susceptibility to Cadmium-Chloride-Induced Toxicity in Mouse Embryonic Fibroblasts. Journal of Toxicology. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-468392
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468392