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Dual PPAR αγ Agonism Normalizes Lipoprotein Profile of Renal Dyslipidemia
Joint Authors
Gause-Nilsson, I.
Alaupovic, P.
Attman, P. O.
Svensson, M. K.
Samuelsson, O.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Chronic kidney disease (CKD) is characterised by specific lipoprotein abnormalities and insulin resistance.
Dual activation of the peroxisome proliferators-activated receptors (PPAR) α and γ can significantly improve insulin sensitivity.
The aim of the study was to investigate the effects of a dual PPAR α/γ agonist on lipoprotein abnormalities in patients with CKD.
One mg of the dual PPAR α/γ agonist tesaglitazar was given once daily during six weeks to CKD patients, and to healthy subjects.
Plasma lipids, apolipoproteins (apo) and discrete lipoprotein subclasses were measured at baseline and end of treatment.
In the CKD patients apoA-I increased significantly by 9%, and apoB decreased by 18%.
There was an increase of apoC-III in HDL by 30%, and a parallel decrease of apoC-III in VLDL + LDL by 13%.
Both the apoB-containing cholesterol-rich and the triglyceride-rich subclasses decreased significantly.
With the exception of ApoC-III,all plasma lipids apolipoproteins and lipoprotein subclasses were reduced by treatment down to similar levels as the baseline levels of a healthy group of reference subjects.
This study suggests that by improving insulin sensitivity a dual PPAR α/γ agonist has the potential to normalise most of the lipoprotein abnormalities in patients with CKD.
American Psychological Association (APA)
Samuelsson, O.& Attman, P. O.& Gause-Nilsson, I.& Svensson, M. K.& Alaupovic, P.. 2013. Dual PPAR αγ Agonism Normalizes Lipoprotein Profile of Renal Dyslipidemia. PPAR Research،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-468444
Modern Language Association (MLA)
Samuelsson, O.…[et al.]. Dual PPAR αγ Agonism Normalizes Lipoprotein Profile of Renal Dyslipidemia. PPAR Research No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-468444
American Medical Association (AMA)
Samuelsson, O.& Attman, P. O.& Gause-Nilsson, I.& Svensson, M. K.& Alaupovic, P.. Dual PPAR αγ Agonism Normalizes Lipoprotein Profile of Renal Dyslipidemia. PPAR Research. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-468444
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468444