Remarkable Role of Indoleamine 2,3-Dioxygenase and Tryptophan Metabolites in Infectious Diseases : Potential Role in Macrophage-Mediated Inflammatory Diseases
Joint Authors
Imamura, Yukio
Hoshi, Masato
Arioka, Yuko
Saito, Kuniaki
Yamamoto, Yasuko
Murakami, Yuki
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Indoleamine 2,3-dioxygenase 1 (IDO1), the L-tryptophan-degrading enzyme, plays a key role in the immunomodulatory effects on several types of immune cells.
Originally known for its regulatory function during pregnancy and chronic inflammation in tumorigenesis, the activity of IDO1 seems to modify the inflammatory state of infectious diseases.
The pathophysiologic activity of L-tryptophan metabolites, kynurenines, is well recognized.
Therefore, an understanding of the regulation of IDO1 and the subsequent biochemical reactions is essential for the design of therapeutic strategies in certain immune diseases.
In this paper, current knowledge about the role of IDO1 and its metabolites during various infectious diseases is presented.
Particularly, the regulation of type I interferons (IFNs) production via IDO1 in virus infection is discussed.
This paper offers insights into new therapeutic strategies in the modulation of viral infection and several immune-related disorders.
American Psychological Association (APA)
Murakami, Yuki& Hoshi, Masato& Imamura, Yukio& Arioka, Yuko& Yamamoto, Yasuko& Saito, Kuniaki. 2013. Remarkable Role of Indoleamine 2,3-Dioxygenase and Tryptophan Metabolites in Infectious Diseases : Potential Role in Macrophage-Mediated Inflammatory Diseases. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-468494
Modern Language Association (MLA)
Murakami, Yuki…[et al.]. Remarkable Role of Indoleamine 2,3-Dioxygenase and Tryptophan Metabolites in Infectious Diseases : Potential Role in Macrophage-Mediated Inflammatory Diseases. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-468494
American Medical Association (AMA)
Murakami, Yuki& Hoshi, Masato& Imamura, Yukio& Arioka, Yuko& Yamamoto, Yasuko& Saito, Kuniaki. Remarkable Role of Indoleamine 2,3-Dioxygenase and Tryptophan Metabolites in Infectious Diseases : Potential Role in Macrophage-Mediated Inflammatory Diseases. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-468494
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468494