DNA Binding and Antitumor Activity of α-Diimineplatinum(II) and Palladium(II) Dithiocarbamate Complexes
Joint Authors
Divsalar, Adeleh
Khosravi, Fatemeh
Saboury, Ali Akbar
Saeidifar, Maryam
Mansouri-Torshizi, Hassan
Mansouri-Torshizi, Hassan
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The two water-soluble designed platinum(II) complex, [Pt(Oct-dtc)(bpy)]NO3 (Oct-dtc = Octyldithiocarbamate and bpy = 2,2′ -bipyridine) and palladium(II) complex, [Pd(Oct-dtc)(bpy)]NO3, have been synthesized and characterized by elemental analyses, molar conductivity measurements, IR, 1H NMR, and electronic spectra studies.
Studies of antitumor activity of these complexes against human cell tumor lines (K562) have been carried out.
They show Ic50 values lower than that of cisplatin.
The complexes have been investigated for their interaction with calf thymus DNA (CT-DNA) by utilizing the electronic absorption spectroscopy, fluorescence spectra, and ethidium bromide displacement and gel filtration techniques.
Both of these water-soluble complexes bound cooperatively and intercalatively to the CT-DNA at very low concentrations.
Several binding and thermodynamic parameters are also described.
American Psychological Association (APA)
Mansouri-Torshizi, Hassan& Saeidifar, Maryam& Khosravi, Fatemeh& Divsalar, Adeleh& Saboury, Ali Akbar& Mansouri-Torshizi, Hassan. 2011. DNA Binding and Antitumor Activity of α-Diimineplatinum(II) and Palladium(II) Dithiocarbamate Complexes. Bioinorganic Chemistry and Applications،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-468677
Modern Language Association (MLA)
Mansouri-Torshizi, Hassan…[et al.]. DNA Binding and Antitumor Activity of α-Diimineplatinum(II) and Palladium(II) Dithiocarbamate Complexes. Bioinorganic Chemistry and Applications No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-468677
American Medical Association (AMA)
Mansouri-Torshizi, Hassan& Saeidifar, Maryam& Khosravi, Fatemeh& Divsalar, Adeleh& Saboury, Ali Akbar& Mansouri-Torshizi, Hassan. DNA Binding and Antitumor Activity of α-Diimineplatinum(II) and Palladium(II) Dithiocarbamate Complexes. Bioinorganic Chemistry and Applications. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-468677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-468677