Thyroid Hormone Receptors in Two Model Species for Vertebrate Embryonic Development : Chicken and Zebrafish
Joint Authors
Van Herck, Stijn L. J.
De Groef, Bert
Darras, Veerle M.
Heijlen, Marjolein
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Chicken and zebrafish are two model species regularly used to study the role of thyroid hormones in vertebrate development.
Similar to mammals, chickens have one thyroid hormone receptor α (TRα) and one TRβ gene, giving rise to three TR isoforms: TRα, TRβ2, and TRβ0, the latter with a very short amino-terminal domain.
Zebrafish also have one TRβ gene, providing two TRβ1 variants.
The zebrafish TRα gene has been duplicated, and at least three TRα isoforms are expressed: TRαA1-2 and TRαB are very similar, while TRαA1 has a longer carboxy-terminal ligand-binding domain.
All these TR isoforms appear to be functional, ligand-binding receptors.
As in other vertebrates, the different chicken and zebrafish TR isoforms have a divergent spatiotemporal expression pattern, suggesting that they also have distinct functions.
Several isoforms are expressed from the very first stages of embryonic development and early chicken and zebrafish embryos respond to thyroid hormone treatment with changes in gene expression.
Future studies in knockdown and mutant animals should allow us to link the different TR isoforms to specific processes in embryonic development.
American Psychological Association (APA)
Darras, Veerle M.& Van Herck, Stijn L. J.& Heijlen, Marjolein& De Groef, Bert. 2011. Thyroid Hormone Receptors in Two Model Species for Vertebrate Embryonic Development : Chicken and Zebrafish. Journal of Thyroid Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-469186
Modern Language Association (MLA)
Darras, Veerle M.…[et al.]. Thyroid Hormone Receptors in Two Model Species for Vertebrate Embryonic Development : Chicken and Zebrafish. Journal of Thyroid Research No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-469186
American Medical Association (AMA)
Darras, Veerle M.& Van Herck, Stijn L. J.& Heijlen, Marjolein& De Groef, Bert. Thyroid Hormone Receptors in Two Model Species for Vertebrate Embryonic Development : Chicken and Zebrafish. Journal of Thyroid Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-469186
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469186