Silica Aerogel Improves the Biocompatibility in a Poly-ε-Caprolactone Composite Used as a Tissue Engineering Scaffold
Joint Authors
Chen, Xiaofeng
Zhang, Qingguo
Yang, Shang-You
Ge, Jianhua
Yang, Christopher Z.
Li, Musen
Wooley, Paul H.
Source
International Journal of Polymer Science
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Poly-ε-caprolactone (PCL) is a biodegradable polyester that has received great attentions in clinical and biomedical applications as sutures, drug delivery tool, and implantable scaffold material.
Silica aerogel is a material composed of SiO2 that has excellent physical properties for use in drug release formulations and biomaterials for tissue engineering.
The current study addresses a composite of silica aerogel with PCL as a potential bone scaffold material for bone tissue engineering.
The biocompatibility evaluation of this composite indicates that the presence of silica aerogel effectively prevented any cytotoxic effects of the PCL membrane during extended tissue culture periods and improved the survival, attachment, and growth of 3T3 cells and primary mouse osteoblastic cells.
The beneficial effect of silica aerogel may be due to neutralization of the acidic condition that develops during PCL degradation.
Specifically, it appears that silica aerogel to PCL wt/wt ratio at 0.5 : 1 maintains a constant pH environment for up to 4 weeks and provides a better environment for cell growth.
American Psychological Association (APA)
Ge, Jianhua& Li, Musen& Zhang, Qingguo& Yang, Christopher Z.& Wooley, Paul H.& Chen, Xiaofeng…[et al.]. 2013. Silica Aerogel Improves the Biocompatibility in a Poly-ε-Caprolactone Composite Used as a Tissue Engineering Scaffold. International Journal of Polymer Science،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-469243
Modern Language Association (MLA)
Ge, Jianhua…[et al.]. Silica Aerogel Improves the Biocompatibility in a Poly-ε-Caprolactone Composite Used as a Tissue Engineering Scaffold. International Journal of Polymer Science No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-469243
American Medical Association (AMA)
Ge, Jianhua& Li, Musen& Zhang, Qingguo& Yang, Christopher Z.& Wooley, Paul H.& Chen, Xiaofeng…[et al.]. Silica Aerogel Improves the Biocompatibility in a Poly-ε-Caprolactone Composite Used as a Tissue Engineering Scaffold. International Journal of Polymer Science. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-469243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469243