Polymorphisms of β1-Adrenoreceptor Gene and Cardiovascular Complications in Patients with Thyrotoxicosis
Joint Authors
Olga, Freylihman
Savitskaja, D. A.
Babenko, A. Y.
Kravchuk, E. N.
Vladislav, Solncev
Elena, Grineva
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Human cardiac β1-AR perform a crucial role in mediating the cardiostimulating effects of norepinephrine.
Gly389Arg and Ser49Gly polymorphisms of β1-adrenoreceptors (β1-AR) can influence the cardiovascular prognosis.
However, the possible effect of Gly389Arg and Ser49Gly polymorphisms on heart function in thyrotoxicosis has not been studied.
We investigated the possible link between Gly389Arg and Ser49Gly polymorphisms and echocardiography parameters in 165 normotensive patients with a thyrotoxicosis without any cardiovascular disorders.
Echo-CG was performed according to standard protocol before and during the thyreostatic treatment.
Our data demonstrate that both Gly389Arg and Ser49Gly polymorphisms have very moderate influence on the risk of left ventricular hypertrophy and atrial fibrillation with no statistically significant effects on cardiac function and the development of cardiovascular complications.
American Psychological Association (APA)
Babenko, A. Y.& Elena, Grineva& Savitskaja, D. A.& Kravchuk, E. N.& Vladislav, Solncev& Olga, Freylihman. 2014. Polymorphisms of β1-Adrenoreceptor Gene and Cardiovascular Complications in Patients with Thyrotoxicosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-469245
Modern Language Association (MLA)
Babenko, A. Y.…[et al.]. Polymorphisms of β1-Adrenoreceptor Gene and Cardiovascular Complications in Patients with Thyrotoxicosis. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-469245
American Medical Association (AMA)
Babenko, A. Y.& Elena, Grineva& Savitskaja, D. A.& Kravchuk, E. N.& Vladislav, Solncev& Olga, Freylihman. Polymorphisms of β1-Adrenoreceptor Gene and Cardiovascular Complications in Patients with Thyrotoxicosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-469245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469245
