Immunogenicity of Simulated PCECV Postexposure Booster Doses 1, 3, and 5 Years after 2-Dose and 3-Dose Primary Rabies Vaccination in Schoolchildren
Joint Authors
Thinyounyong, Wiravan
Khawplod, Pakamatz
Malerczyk, Claudius
Phongchamnaphai, Phana
Kamoltham, Thavatchai
Anders, Gerlind
Phraisuwan, Phran
Source
Advances in Preventive Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
To assess the immunogenicity of intradermal (ID) booster doses of Purified Chick Embryo Cell rabies vaccine (PCECV, Rabipur) administered to Thai schoolchildren one, three and five years after a primary ID pre-exposure (PrEP) vaccination series.
Methods.
In this follow-up study of a randomized, open-label, phase II clinical trial, two simulated post-exposure booster doses of PCECV were administered on days 0 and 3 intradermally to 703 healthy schoolchildren, one, three or five years after primary vaccination with either two or three ID doses of 0.1 mL PCECV.
Blood was drawn immediately before and 7, 14 and 365 days after the first booster dose to determine rabies virus neutralizing antibody (RVNA) concentrations.
Results.
An anamnestic response of approximately 30-fold increase in RVNA concentrations was demonstrated within 14 days after booster.
All children (100%) developed adequate RVNA concentrations above 0.5 IU/mL.
No vaccine related serious adverse events were seen in any of the vaccinees.
Conclusion.
ID rabies PrEP with PCECV is safe and immunogenic in schoolchildren and the anamnestic response to a two booster dose vaccination series was found to be adequate one, three, and five years after a two- or three-dose primary PrEP vaccination series.
American Psychological Association (APA)
Kamoltham, Thavatchai& Thinyounyong, Wiravan& Khawplod, Pakamatz& Phraisuwan, Phran& Phongchamnaphai, Phana& Anders, Gerlind…[et al.]. 2011. Immunogenicity of Simulated PCECV Postexposure Booster Doses 1, 3, and 5 Years after 2-Dose and 3-Dose Primary Rabies Vaccination in Schoolchildren. Advances in Preventive Medicine،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-469272
Modern Language Association (MLA)
Kamoltham, Thavatchai…[et al.]. Immunogenicity of Simulated PCECV Postexposure Booster Doses 1, 3, and 5 Years after 2-Dose and 3-Dose Primary Rabies Vaccination in Schoolchildren. Advances in Preventive Medicine No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-469272
American Medical Association (AMA)
Kamoltham, Thavatchai& Thinyounyong, Wiravan& Khawplod, Pakamatz& Phraisuwan, Phran& Phongchamnaphai, Phana& Anders, Gerlind…[et al.]. Immunogenicity of Simulated PCECV Postexposure Booster Doses 1, 3, and 5 Years after 2-Dose and 3-Dose Primary Rabies Vaccination in Schoolchildren. Advances in Preventive Medicine. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-469272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469272