eNOS Gene Variant in Patients with Coronary Artery Disease
Joint Authors
Abolhalaj, Milad
Amiri, Parvin
Amoli, Mahsa M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Subject & Aim.
Endothelial nitric oxide synthase (eNOS) is one of the most important candidate genes in CAD.
A functional polymorphism within eNOS gene is a 27 bp VNTR on its intron 4 which has been shown to be associated with various diseases.
In this study we investigated eNOS VNTR polymorphism in addition to eNOS gene expression profile in patients with CAD.
Material and Methods.
The study comprised patients with angiographically confirmed CAD (CAD+) and individuals with normal coronary as CAD−.
eNOS VNTR polymorphism frequencies were determined in both groups.
In addition eNOS gene expression profile was examined using a quantitative real-time PCR.
Results.
We have found that aa genotype was significantly increasing the risk of CAD in our patients (aa versus ab + bb, P=0.02, OR=3.5; 95% CI: = 0.98 to 16.2).
The differences in eNOS expression were not significant between patients and normal group; however in CAD+ patients eNOS expression was higher than the expression level of patients carrying other genotypes (P=0.16).
Conclusion.
We have observed that eNOS gene polymorphism was associated with CAD in angiography-confirmed patients.
However, the difference in eNOS gene expression was not statistically significant between patients and control which might be due to the contribution of other confounding factors which require further investigations.
American Psychological Association (APA)
Abolhalaj, Milad& Amoli, Mahsa M.& Amiri, Parvin. 2012. eNOS Gene Variant in Patients with Coronary Artery Disease. Journal of Biomarkers،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-469323
Modern Language Association (MLA)
Abolhalaj, Milad…[et al.]. eNOS Gene Variant in Patients with Coronary Artery Disease. Journal of Biomarkers No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-469323
American Medical Association (AMA)
Abolhalaj, Milad& Amoli, Mahsa M.& Amiri, Parvin. eNOS Gene Variant in Patients with Coronary Artery Disease. Journal of Biomarkers. 2012. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-469323
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469323