Growth Arrest Specific Gene 6 Protein Concentration in Cerebrospinal Fluid Correlates with Relapse Severity in Multiple Sclerosis

Joint Authors

Monaco, F.
Ranza, E.
Collimedaglia, L.
Pirisi, M.
Sola, D.
Sainaghi, P. P.
Avanzi, G. C.
Molinari, R.
Leone, Maurizio
Naldi, P.
Alciato, F.

Source

Mediators of Inflammation

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-05-27

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases

Abstract EN

Background.

Growth arrest specific gene 6 (Gas6) protein enhances survival of oligodendrocytes and neurons, and it is involved in autoimmunity.

Therefore, we aimed to verify whether cerebrospinal-fluid (CSF) Gas6 concentration may represent a biomarker of disease activity in multiple sclerosis.

Methods.

Sixty-five patients who underwent a spinal tap during relapse of relapsing/remitting multiple sclerosis (RR-MS)(McDonald-criteria) were studied.

Forty patients affected by noninflammatory/nonautoimmune neurological diseases served as controls.

Relapse was defined according to Schumacher criteria.

Symptoms were grouped according to Kurtzke-Functional System (FS).

Clinical characteristics of the relapse, duration, Expanded-Disability-Status Scale (EDSS) change, number of FS involved, completeness of recovery, age, steroid therapy, were categorised.

Patients were followed at 6-month intervals to assess relapse rate and EDSS progression.

Gas6 was measured (CSF, plasma) by in-house-enzyme-linked immunoassay (ELISA).

Results.

Higher CSF Gas6 concentrations were observed in relapses lasting ≤60 days (8.7 ± 3.9 ng/mL) versus >60 days (6.5 ± 2.6) or controls (6.5 ± 2.4; P=0.05), with ≤2 FS involved (8.5 ± 3.8) versus >2 FS (5.6 ± 2.5) (P<0.05) and EDSS change ≤2.5 points (8.8 ± 3.7) versus >2.5 (6.5 ± 3.5) (P=0.04).

Conversely, CSF Gas6 was not predictive of the completeness of recovery.

Plasma and CSF concentrations were not related (R2=0.0003), and neither were predictive of relapse rate or EDSS progression after first relapse.

Conclusions.

CSF concentration of Gas6 is inversely correlated with the severity of relapse in RR-MS patients but does not predict the subsequent course of the disease.

American Psychological Association (APA)

Sainaghi, P. P.& Collimedaglia, L.& Alciato, F.& Molinari, R.& Sola, D.& Ranza, E.…[et al.]. 2013. Growth Arrest Specific Gene 6 Protein Concentration in Cerebrospinal Fluid Correlates with Relapse Severity in Multiple Sclerosis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-469593

Modern Language Association (MLA)

Sainaghi, P. P.…[et al.]. Growth Arrest Specific Gene 6 Protein Concentration in Cerebrospinal Fluid Correlates with Relapse Severity in Multiple Sclerosis. Mediators of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-469593

American Medical Association (AMA)

Sainaghi, P. P.& Collimedaglia, L.& Alciato, F.& Molinari, R.& Sola, D.& Ranza, E.…[et al.]. Growth Arrest Specific Gene 6 Protein Concentration in Cerebrospinal Fluid Correlates with Relapse Severity in Multiple Sclerosis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-469593

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-469593