Dysfunction of Lacrimal and Salivary Glands in Sjögren's Syndrome : Nonimmunologic Injury in Preinflammatory Phase and Mouse Model
Author
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-01
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Sjögren's syndrome (SjS) is a chronic autoimmune disorder characterized by dry eyes and dry mouth due to dacryoadenitis and sialoadenitis with SS-A/Ro and/or SS-B/La autoantibodies in genetically predisposed individuals.
Destruction of lacrimal and salivary glands by autoimmune reactions may lead to clinical manifestation.
However, the mechanisms behind the decreased volume of secretions in tears and saliva are complex and are not fully understood.
Exocrine gland dysfunction may precede autoimmunity (acquired immunity) or represent a process independent from inflammation in the pathogenesis of SjS.
The preceded functional and morphologic changes of those tissues by nonimmunologic injury before the development of inflammation at the sites of target organs have been implicated.
This paper focuses on the several factors and components relating to glandular dysfunction and morphologic changes by nonimmunologic injury during the preinflammatory phase in mouse model, including the factors which link between innate immunity and adaptive immunity.
American Psychological Association (APA)
Hayashi, Toshiharu. 2011. Dysfunction of Lacrimal and Salivary Glands in Sjögren's Syndrome : Nonimmunologic Injury in Preinflammatory Phase and Mouse Model. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-469643
Modern Language Association (MLA)
Hayashi, Toshiharu. Dysfunction of Lacrimal and Salivary Glands in Sjögren's Syndrome : Nonimmunologic Injury in Preinflammatory Phase and Mouse Model. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-469643
American Medical Association (AMA)
Hayashi, Toshiharu. Dysfunction of Lacrimal and Salivary Glands in Sjögren's Syndrome : Nonimmunologic Injury in Preinflammatory Phase and Mouse Model. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-469643
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469643