PPARG : Gene Expression Regulation and Next-Generation Sequencing for Unsolved Issues
Joint Authors
Letizia, Francesca
Costa, Valerio
Gallo, Maria Assunta
Aprile, Marianna
Ciccodicola, Alfredo
Casamassimi, Amelia
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-08
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptor gamma (PPARγ) is one of the most extensively studied ligand-inducible transcription factors (TFs), able to modulate its transcriptional activity through conformational changes.
It is of particular interest because of its pleiotropic functions: it plays a crucial role in the expression of key genes involved in adipogenesis, lipid and glucid metabolism, atherosclerosis, inflammation, and cancer.
Its protein isoforms, the wide number of PPARγ target genes, ligands, and coregulators contribute to determine the complexity of its function.
In addition, the presence of genetic variants is likely to affect expression levels of target genes although the impact of PPARG gene variations on the expression of target genes is not fully understood.
The introduction of massively parallel sequencing platforms—in the Next Generation Sequencing (NGS) era—has revolutionized the way of investigating the genetic causes of inherited diseases.
In this context, DNA-Seq for identifying—within both coding and regulatory regions of PPARG gene—novel nucleotide variations and haplotypes associated to human diseases, ChIP-Seq for defining a PPARγ binding map, and RNA-Seq for unraveling the wide and intricate gene pathways regulated by PPARG, represent incredible steps toward the understanding of PPARγ in health and disease.
American Psychological Association (APA)
Costa, Valerio& Gallo, Maria Assunta& Letizia, Francesca& Aprile, Marianna& Casamassimi, Amelia& Ciccodicola, Alfredo. 2010. PPARG : Gene Expression Regulation and Next-Generation Sequencing for Unsolved Issues. PPAR Research،Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-469853
Modern Language Association (MLA)
Costa, Valerio…[et al.]. PPARG : Gene Expression Regulation and Next-Generation Sequencing for Unsolved Issues. PPAR Research No. 2010 (2010), pp.1-17.
https://search.emarefa.net/detail/BIM-469853
American Medical Association (AMA)
Costa, Valerio& Gallo, Maria Assunta& Letizia, Francesca& Aprile, Marianna& Casamassimi, Amelia& Ciccodicola, Alfredo. PPARG : Gene Expression Regulation and Next-Generation Sequencing for Unsolved Issues. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-469853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469853