Phases 1–3 Clinical Trials Using Adult Stem Cells in Osteonecrosis and Nonunion Fractures
Joint Authors
Hauzeur, Jean-Philippe
Gangji, Valérie
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Nonunion fractures and aseptic bone necrosis are two pathological conditions having some impairment of the cellular part of the repair: a reduction of MSC and of the osteoblastic activation.
Both are good candidates for cell-based therapies using stem cells.
We made a review of the published human trials.
Only autologous bone marrow aspirate implantation was until now used.
In Nonunion, a direct injection—15 to 150 ml—was made in 4 case series studies.
In another, the bone marrow aspirate was concentrated before injection.
The results were good.
In bone necrosis, only one level 1 study was published.
The results at 24 months were positive in terms of reduction of the necrosis and appearance of collapse.
In 3 case series studies, a treatment with concentrated bone marrow aspirates was deemed useful with good results in 76 to 96%.
These results are interesting but need confirmation by controlled studies.
American Psychological Association (APA)
Hauzeur, Jean-Philippe& Gangji, Valérie. 2010. Phases 1–3 Clinical Trials Using Adult Stem Cells in Osteonecrosis and Nonunion Fractures. Stem Cells International،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-469932
Modern Language Association (MLA)
Hauzeur, Jean-Philippe& Gangji, Valérie. Phases 1–3 Clinical Trials Using Adult Stem Cells in Osteonecrosis and Nonunion Fractures. Stem Cells International No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-469932
American Medical Association (AMA)
Hauzeur, Jean-Philippe& Gangji, Valérie. Phases 1–3 Clinical Trials Using Adult Stem Cells in Osteonecrosis and Nonunion Fractures. Stem Cells International. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-469932
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469932