Optimizing a Rodent Model of Parkinson's Disease for Exploring the Effects and Mechanisms of Deep Brain Stimulation
Joint Authors
Benecke, Reiner
Nowak, Karl
Gimsa, Ulrike
Mix, Eilhard
Sriperumbudur, Kiran Kumar
Gimsa, Jan
Strauss, Ulf
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-05
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Deep brain stimulation (DBS) has become a treatment for a growing number of neurological and psychiatric disorders, especially for therapy-refractory Parkinson's disease (PD).
However, not all of the symptoms of PD are sufficiently improved in all patients, and side effects may occur.
Further progress depends on a deeper insight into the mechanisms of action of DBS in the context of disturbed brain circuits.
For this, optimized animal models have to be developed.
We review not only charge transfer mechanisms at the electrode/tissue interface and strategies to increase the stimulation's energy-efficiency but also the electrochemical, electrophysiological, biochemical and functional effects of DBS.
We introduce a hemi-Parkinsonian rat model for long-term experiments with chronically instrumented rats carrying a backpack stimulator and implanted platinum/iridium electrodes.
This model is suitable for (1) elucidating the electrochemical processes at the electrode/tissue interface, (2) analyzing the molecular, cellular and behavioral stimulation effects, (3) testing new target regions for DBS, (4) screening for potential neuroprotective DBS effects, and (5) improving the efficacy and safety of the method.
An outlook is given on further developments of experimental DBS, including the use of transgenic animals and the testing of closed-loop systems for the direct on-demand application of electric stimulation.
American Psychological Association (APA)
Nowak, Karl& Mix, Eilhard& Gimsa, Jan& Strauss, Ulf& Sriperumbudur, Kiran Kumar& Benecke, Reiner…[et al.]. 2011. Optimizing a Rodent Model of Parkinson's Disease for Exploring the Effects and Mechanisms of Deep Brain Stimulation. Journal of Oncology،Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-470274
Modern Language Association (MLA)
Nowak, Karl…[et al.]. Optimizing a Rodent Model of Parkinson's Disease for Exploring the Effects and Mechanisms of Deep Brain Stimulation. Journal of Oncology No. 2011 (2011), pp.1-19.
https://search.emarefa.net/detail/BIM-470274
American Medical Association (AMA)
Nowak, Karl& Mix, Eilhard& Gimsa, Jan& Strauss, Ulf& Sriperumbudur, Kiran Kumar& Benecke, Reiner…[et al.]. Optimizing a Rodent Model of Parkinson's Disease for Exploring the Effects and Mechanisms of Deep Brain Stimulation. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-19.
https://search.emarefa.net/detail/BIM-470274
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470274