Evaluation of the Pattern of EPIYA Motifs in the Helicobacter pylori cagA Gene of Patients with Gastritis and Gastric Adenocarcinoma from the Brazilian Amazon Region
Joint Authors
da Costa, Renata Aparecida Andrade
Fecury, Amanda Alves
Quaresma, Juarez Antônio Simões
Junior, Mario Ribeiro da Silva
Vinagre, Ruth Maria Dias Ferreira
Martins, Luisa Caricio
Vilar e Silva, Adenielson
Santos, Kemper Nunes
Source
International Journal of Bacteriology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The Helicobacter pylori is associated with the development of different diseases.
The clinical outcome of infection may be associated with the cagA bacterial genotype.
The aim of this study was to determine the EPIYA patterns of strains isolated from patients with gastritis and gastric adenocarcinoma and correlate these patterns with the histopathological features.
Gastric biopsy samples were selected from 384 patients infected with H.
pylori, including 194 with chronic gastritis and 190 with gastric adenocarcinoma.
The presence of the cagA gene and the EPIYA motif was determined by PCR.
The cagA gene was more prevalent in patients with gastric cancer and was associated with a higher degree of inflammation, neutrophil activity, and development of intestinal metaplasia.
The number of EPIYA-C repeats showed a significant association with an increased risk of gastric carcinoma (OR = 3.79, 95% CI = 1.92–7.46, and P=0.002).
A larger number of EPIYA-C motifs were also associated with intestinal metaplasia.
In the present study, infection with H.
pylori strains harboring more than one EPIYA-C motif in the cagA gene was associated with the development of intestinal metaplasia and gastric adenocarcinoma but not with neutrophil activity or degree of inflammation.
American Psychological Association (APA)
Vilar e Silva, Adenielson& Junior, Mario Ribeiro da Silva& Vinagre, Ruth Maria Dias Ferreira& Santos, Kemper Nunes& da Costa, Renata Aparecida Andrade& Fecury, Amanda Alves…[et al.]. 2014. Evaluation of the Pattern of EPIYA Motifs in the Helicobacter pylori cagA Gene of Patients with Gastritis and Gastric Adenocarcinoma from the Brazilian Amazon Region. International Journal of Bacteriology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-470603
Modern Language Association (MLA)
Vilar e Silva, Adenielson…[et al.]. Evaluation of the Pattern of EPIYA Motifs in the Helicobacter pylori cagA Gene of Patients with Gastritis and Gastric Adenocarcinoma from the Brazilian Amazon Region. International Journal of Bacteriology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-470603
American Medical Association (AMA)
Vilar e Silva, Adenielson& Junior, Mario Ribeiro da Silva& Vinagre, Ruth Maria Dias Ferreira& Santos, Kemper Nunes& da Costa, Renata Aparecida Andrade& Fecury, Amanda Alves…[et al.]. Evaluation of the Pattern of EPIYA Motifs in the Helicobacter pylori cagA Gene of Patients with Gastritis and Gastric Adenocarcinoma from the Brazilian Amazon Region. International Journal of Bacteriology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-470603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470603