Substance P Regulates Environmental Tobacco Smoke-Enhanced Tracheal Smooth Muscle Responsiveness in Mice
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Environmental tobacco smoke (ETS) is an environmental trigger that leads to airway inflammation and airway hyperresponsiveness (AHR) in susceptible individuals and animals, but the underlying mechanism is not fully understood.
Substance P (SP) release from sensory nerve fibers has been linked to AHR.
The present experiments characterize the role of SP in tracheal smooth muscle on ETS-increased airway responses.
The mice were exposed to either sidestream tobacco smoke (SS), a surrogate to ETS, or filtered air (FA) for 1 day or 5 consecutive days.
Contractions of tracheal smooth muscle to SP and electrical field stimulation (EFS) were not significantly altered in 1 of day SS-exposed mice.
However, 5 of days SS exposure significantly increased airway smooth muscle contractions to SP and EFS.
Administration of CP-99994, an antagonist of the neurokinin (NK)1 receptor, attenuates the SS exposure-enhanced tracheal smooth muscle responses to EFS.
Furthermore, the immunohistochemistry showed that SP nerve fibers were increased in tracheal smooth muscle after 5 of days SS exposure.
These results suggest that the increased SP production may contribute to SS-enhanced smooth muscle responsiveness in mice trachea.
American Psychological Association (APA)
Xiao, Lan& Wu, Zhong-Xin. 2012. Substance P Regulates Environmental Tobacco Smoke-Enhanced Tracheal Smooth Muscle Responsiveness in Mice. Journal of Allergy،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-471019
Modern Language Association (MLA)
Xiao, Lan& Wu, Zhong-Xin. Substance P Regulates Environmental Tobacco Smoke-Enhanced Tracheal Smooth Muscle Responsiveness in Mice. Journal of Allergy No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-471019
American Medical Association (AMA)
Xiao, Lan& Wu, Zhong-Xin. Substance P Regulates Environmental Tobacco Smoke-Enhanced Tracheal Smooth Muscle Responsiveness in Mice. Journal of Allergy. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-471019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471019