Heart-Kidney Biomarkers in Patients Undergoing Cardiac Stress Testing
Joint Authors
House, Andrew A.
de Cal, Massimo
Zanco, Pierluigi
Fontanelli, Alessandro
Ronco, Claudio
Soffiati, Giuliano
Cruz, Dinna N.
Fortunato, Antonio
Haapio, Mikko
Salgarello, Matteo
Lupi, Andrea
Lentini, Paolo
Giavarina, Davide
Menghetti, Luigi
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We examined association of inducible myocardial perfusion defects with cardiorenal biomarkers, and of diminished left ventricular ejection fraction (LVEF) with kidney injury marker plasma neutrophil gelatinase-associated lipocalin (NGAL).
Patients undergoing nuclear myocardial perfusion stress imaging were divided into 2 groups.
Biomarkers were analyzed pre- and poststress testing.
Compared to the patients in the low ischemia group (n=16), the patients in the high ischemia group (n=18) demonstrated a significantly greater rise in cardiac biomarkers plasma BNP, NT-proBNP and cTnI.
Subjects were also categorized based on pre- or poststress test detectable plasma NGAL.
With stress, the group with no detectable NGAL had a segmental defect score 4.2 compared to 8.2 (P=.06) in the detectable NGAL group, and 0.9 vs.
3.8 (P=.03) at rest.
BNP rose with stress to a greater degree in patients with detectable NGAL (10.2 vs.
3.5 pg/mL, P=.03).
LVEF at rest and with stress was significantly lower in the detectable NGAL group; 55.8 versus 65.0 (P=.03) and 55.1 vs.
63.8 (P=.04), respectively.
Myocardial perfusion defects associate with biomarkers of cardiac stress, and detectable plasma NGAL with significantly lower LVEF, suggesting a specific heart-kidney link.
American Psychological Association (APA)
Haapio, Mikko& House, Andrew A.& de Cal, Massimo& Cruz, Dinna N.& Lentini, Paolo& Giavarina, Davide…[et al.]. 2010. Heart-Kidney Biomarkers in Patients Undergoing Cardiac Stress Testing. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-471227
Modern Language Association (MLA)
Haapio, Mikko…[et al.]. Heart-Kidney Biomarkers in Patients Undergoing Cardiac Stress Testing. International Journal of Nephrology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-471227
American Medical Association (AMA)
Haapio, Mikko& House, Andrew A.& de Cal, Massimo& Cruz, Dinna N.& Lentini, Paolo& Giavarina, Davide…[et al.]. Heart-Kidney Biomarkers in Patients Undergoing Cardiac Stress Testing. International Journal of Nephrology. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-471227
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471227