Circadian Models of Serum Potassium, Sodium, and Calcium Concentrations in Healthy Individuals and Their Application to Cardiac Electrophysiology Simulations at Individual Level
Joint Authors
Fijorek, Kamil
Polak, Sebastian
Puskulluoglu, Miroslawa
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In the article a brief description of the biological basis of the regulation of human biological clocks was presented in order to introduce the role of circadian rhythms in physiology and specifically in the pharmacological translational tools based on the computational physiology models to motivate the need to provide models of circadian fluctuation in plasma cations.
The main aim of the study was to develop statistical models of the circadian rhythm of potassium, sodium, and calcium concentrations in plasma.
The developed ion models were further tested by assessing their influence on QT duration (cardiac endpoint) as simulated by the biophysically detailed models of human left ventricular cardiomyocyte.
The main results are model equations along with an electronic supplement to the article that contains a fully functional implementation of all models.
American Psychological Association (APA)
Fijorek, Kamil& Puskulluoglu, Miroslawa& Polak, Sebastian. 2013. Circadian Models of Serum Potassium, Sodium, and Calcium Concentrations in Healthy Individuals and Their Application to Cardiac Electrophysiology Simulations at Individual Level. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-471534
Modern Language Association (MLA)
Fijorek, Kamil…[et al.]. Circadian Models of Serum Potassium, Sodium, and Calcium Concentrations in Healthy Individuals and Their Application to Cardiac Electrophysiology Simulations at Individual Level. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-471534
American Medical Association (AMA)
Fijorek, Kamil& Puskulluoglu, Miroslawa& Polak, Sebastian. Circadian Models of Serum Potassium, Sodium, and Calcium Concentrations in Healthy Individuals and Their Application to Cardiac Electrophysiology Simulations at Individual Level. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-471534
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471534