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E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity
Joint Authors
Kume, Toshiaki
Murakami, Kazuma
Nishizaki, Tomoyuki
Suzuki, Takayuki
Tomiyama, Takami
Takuma, Hiroshi
Nagata, Tetsu
Mori, Hiroshi
Izuo, Naotaka
Akaike, Akinori
Irie, Kazuhiro
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Oligomers of 40- or 42-mer amyloid β-protein (Aβ40, Aβ42) cause cognitive decline and synaptic dysfunction in Alzheimer's disease.
We proposed the importance of a turn at Glu22 and Asp23 of Aβ42 to induce its neurotoxicity through the formation of radicals.
Recently, a novel deletion mutant at Glu22 (E22Δ) of Aβ42 was reported to accelerate oligomerization and synaptotoxicity.
To investigate this mechanism, the effects of the E22Δ mutation in Aβ42 and Aβ40 on the transformation of β-sheets, radical production, and neurotoxicity were examined.
Both mutants promoted β-sheet transformation and the formation of radicals, while their neurotoxicity was negative.
In contrast, E22P-Aβ42 with a turn at Glu22 and Asp23 exhibited potent neurotoxicity along with the ability to form radicals and potent synaptotoxicity.
These data suggest that conformational change in E22Δ-Aβ is similar to that in E22P-Aβ42 but not the same, since E22Δ-Aβ42 exhibited no cytotoxicity, unlike E22P-Aβ42 and wild-type Aβ42.
American Psychological Association (APA)
Suzuki, Takayuki& Murakami, Kazuma& Izuo, Naotaka& Kume, Toshiaki& Akaike, Akinori& Nagata, Tetsu…[et al.]. 2010. E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-471740
Modern Language Association (MLA)
Suzuki, Takayuki…[et al.]. E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-471740
American Medical Association (AMA)
Suzuki, Takayuki& Murakami, Kazuma& Izuo, Naotaka& Kume, Toshiaki& Akaike, Akinori& Nagata, Tetsu…[et al.]. E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity. International Journal of Alzheimer's Disease. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-471740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471740