In Vitro Characterization of Six Month Dosage Forms for a GnRH Antagonist
Joint Authors
Faraj, Jabar A.
Murty, Santos
D'Souza, Susan
DeLuca, Patrick P.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
The objective of this study was to develop long-acting injectable dosage forms of Orntide, a peptide GnRH antagonist, to provide tailored release for 6-month duration.
Using a polylactide homopolymer and the solvent extraction/evaporation method, three microsphere formulations (Formulations A, B, and C) were prepared at various drug loadings (11.85–15.79%).
The microspheres were characterized for particle size by laser diffractometry, surface morphology by scanning electron microscopy (SEM), and bulk density by tapping, as well as long-term in vitro drug release, mass loss and hydration at 37°C, and short-term in vitro drug release at elevated temperatures (51–59°C).
Experiments at 37°C revealed that drug release was triphasic and occurred due to slow degradation of the polylactide polymer.
Short-term in vitro release results indicated that drug release was diffusional.
Application of the Higuchi equation to short-term release confirmed the temperature dependency of the diffusional rate constant.
Using the rate constant and the Arrhenius equation, an Ea value of 45 kcal/mol (Formulation A) and approximately 25 kcal/mol (Formulations B and C) was obtained for diffusional release.
Study results suggest that by selection of an appropriate biodegradable polymer, injectable dosing forms that release drug for 6 months or longer can be developed.
American Psychological Association (APA)
D'Souza, Susan& Murty, Santos& Faraj, Jabar A.& DeLuca, Patrick P.. 2014. In Vitro Characterization of Six Month Dosage Forms for a GnRH Antagonist. Advances in Pharmaceutics،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-472082
Modern Language Association (MLA)
D'Souza, Susan…[et al.]. In Vitro Characterization of Six Month Dosage Forms for a GnRH Antagonist. Advances in Pharmaceutics No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-472082
American Medical Association (AMA)
D'Souza, Susan& Murty, Santos& Faraj, Jabar A.& DeLuca, Patrick P.. In Vitro Characterization of Six Month Dosage Forms for a GnRH Antagonist. Advances in Pharmaceutics. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-472082
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472082