Trafficked Proteins—Druggable in Plasmodium falciparum?
Joint Authors
Lindner, Jasmin
Meissner, Kamila Anna
Schettert, Isolmar
Wrenger, Carsten
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Malaria is an infectious disease that results in serious health problems in the countries in which it is endemic.
Annually this parasitic disease leads to more than half a million deaths; most of these are children in Africa.
An effective vaccine is not available, and the treatment of the disease is solely dependent on chemotherapy.
However, drug resistance is spreading, and the identification of new drug targets as well as the development of new antimalarials is urgently required.
Attention has been drawn to a variety of essential plasmodial proteins, which are targeted to intra- or extracellular destinations, such as the digestive vacuole, the apicoplast, or into the host cell.
Interfering with the action or the transport of these proteins will impede proliferation of the parasite.
In this mini review, we will shed light on the present discovery of chemotherapeutics and potential drug targets involved in protein trafficking processes in the malaria parasite.
American Psychological Association (APA)
Lindner, Jasmin& Meissner, Kamila Anna& Schettert, Isolmar& Wrenger, Carsten. 2013. Trafficked Proteins—Druggable in Plasmodium falciparum?. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-472083
Modern Language Association (MLA)
Lindner, Jasmin…[et al.]. Trafficked Proteins—Druggable in Plasmodium falciparum?. International Journal of Cell Biology No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-472083
American Medical Association (AMA)
Lindner, Jasmin& Meissner, Kamila Anna& Schettert, Isolmar& Wrenger, Carsten. Trafficked Proteins—Druggable in Plasmodium falciparum?. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-472083
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472083