Fractalkine (CX3CL1) and Its Receptor CX3CR1 May Contribute to Increased Angiogenesis in Diabetic Placenta
Joint Authors
Szewczyk, Grzegorz
Szukiewicz, Dariusz
Pyzlak, Michal
Mittal, Tarun Kumar
Stangret, Aleksandra
Kochanowski, Jan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Chemokine CX3CL1 is unique, possessing the ability to act as a dual agent: chemoattractant and adhesive compound.
Acting via its sole receptor CX3CR1, CX3CL1 participates in many processes in human placental tissue, including inflammation and angiogenesis.
Strongly upregulated by hypoxia and/or inflammation-induced inflammatory cytokines secretion, CX3CL1 may act locally as a key angiogenic factor.
Both clinical observations and histopathological studies of the diabetic placenta have confirmed an increased incidence of hypoxia and inflammatory reactions with defective angiogenesis.
In this study we examined comparatively (diabetes class C complicated versus normal pregnancy) the correlation between CX3CL1 content in placental tissue, the mean CX3CR1 expression, and density of the network of placental microvessels.
A sandwich enzyme immunoassay was applied for CX3CL1 measurement in placental tissue homogenates, whereas quantitative immunohistochemical techniques were used for the assessment of CX3CR1 expression and the microvascular density.
Significant differences have been observed for all analyzed parameters between the groups.
The mean concentration of CX3CL1 in diabetes was increased and accompanied by augmented placental microvessel density as well as a higher expression of CX3CR1.
In conclusion, we suggest involvement of CX3CL1/CX3CR1 signaling pathway in the pathomechanism of placental microvasculature remodeling in diabetes class C.
American Psychological Association (APA)
Szukiewicz, Dariusz& Kochanowski, Jan& Pyzlak, Michal& Szewczyk, Grzegorz& Stangret, Aleksandra& Mittal, Tarun Kumar. 2013. Fractalkine (CX3CL1) and Its Receptor CX3CR1 May Contribute to Increased Angiogenesis in Diabetic Placenta. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-472276
Modern Language Association (MLA)
Szukiewicz, Dariusz…[et al.]. Fractalkine (CX3CL1) and Its Receptor CX3CR1 May Contribute to Increased Angiogenesis in Diabetic Placenta. Mediators of Inflammation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-472276
American Medical Association (AMA)
Szukiewicz, Dariusz& Kochanowski, Jan& Pyzlak, Michal& Szewczyk, Grzegorz& Stangret, Aleksandra& Mittal, Tarun Kumar. Fractalkine (CX3CL1) and Its Receptor CX3CR1 May Contribute to Increased Angiogenesis in Diabetic Placenta. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-472276
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472276