Effects of Open versus Laparoscopic Nephrectomy Techniques on Oxidative Stress Markers in Patients with Renal Cell Carcinoma
Joint Authors
Rajewski, Paweł
Woźniak, Alina
Krzyżyńska-Malinowska, Ewa
Drewa, Tomasz
Szpinda, Michał
Mila-Kierzenkowska, Celestyna
Woźniak, Bartosz
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The aim of the study was to determine the concentration of lipid peroxidation products, the activity of selected antioxidant and lysosomal enzymes, and protease inhibitor in patients with renal cell carcinoma who underwent radical nephrectomy.
The studied group included 44 patients: 21 of them underwent open surgery, while 23 underwent laparoscopy.
Blood samples were collected three times: before treatment and 12 hours and five days after nephrectomy.
In blood of participants, the concentration of thiobarbituric acid reactive substances (TBARS), the activity of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx), and the activity of acid phosphatase (AcP), arylsulfatase (ASA), cathepsin D (CTSD), and α1-antitrypsin (AAT) were assayed.
No statistically significant differences in investigated parameters were found between studied groups.
Moreover, TBARS concentration and CAT, SOD, and GPx activity were not altered in the course of both types of surgery.
Five days after both open and laparoscopic nephrectomy techniques, AAT activity was higher than its activity 12 hours after the procedure.
The obtained results suggest that laparoscopy may be used for nephrectomy as effectively as open surgery without creating greater oxidative stress.
Reduced period of convalescence at patients treated with laparoscopy may be due to less severe response of acute-phase proteins.
American Psychological Association (APA)
Mila-Kierzenkowska, Celestyna& Woźniak, Alina& Drewa, Tomasz& Woźniak, Bartosz& Szpinda, Michał& Krzyżyńska-Malinowska, Ewa…[et al.]. 2013. Effects of Open versus Laparoscopic Nephrectomy Techniques on Oxidative Stress Markers in Patients with Renal Cell Carcinoma. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-472339
Modern Language Association (MLA)
Mila-Kierzenkowska, Celestyna…[et al.]. Effects of Open versus Laparoscopic Nephrectomy Techniques on Oxidative Stress Markers in Patients with Renal Cell Carcinoma. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-472339
American Medical Association (AMA)
Mila-Kierzenkowska, Celestyna& Woźniak, Alina& Drewa, Tomasz& Woźniak, Bartosz& Szpinda, Michał& Krzyżyńska-Malinowska, Ewa…[et al.]. Effects of Open versus Laparoscopic Nephrectomy Techniques on Oxidative Stress Markers in Patients with Renal Cell Carcinoma. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-472339
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472339