Novel Approach for Coexpression Analysis of E2F1–3 and MYC Target Genes in Chronic Myelogenous Leukemia
Joint Authors
Wong, S. C. Cesar
Chan, Lawrence W. C.
Tang, Petrus
Wang, Fengfeng
Yung, Benjamin Y. M.
Cho, William Chi-Shing
Yu, Jun
Siu, Parco M.
Yip, Shea Ping
Tsui, Nancy B. Y.
Shyu, Chi-Ren
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Chronic myelogenous leukemia (CML) is characterized by tremendous amount of immature myeloid cells in the blood circulation.
E2F1–3 and MYC are important transcription factors that form positive feedback loops by reciprocal regulation in their own transcription processes.
Since genes regulated by E2F1–3 or MYC are related to cell proliferation and apoptosis, we wonder if there exists difference in the coexpression patterns of genes regulated concurrently by E2F1–3 and MYC between the normal and the CML states.
Results.
We proposed a method to explore the difference in the coexpression patterns of those candidate target genes between the normal and the CML groups.
A disease-specific cutoff point for coexpression levels that classified the coexpressed gene pairs into strong and weak coexpression classes was identified.
Our developed method effectively identified the coexpression pattern differences from the overall structure.
Moreover, we found that genes related to the cell adhesion and angiogenesis properties were more likely to be coexpressed in the normal group when compared to the CML group.
Conclusion.
Our findings may be helpful in exploring the underlying mechanisms of CML and provide useful information in cancer treatment.
American Psychological Association (APA)
Wang, Fengfeng& Chan, Lawrence W. C.& Cho, William Chi-Shing& Tang, Petrus& Yu, Jun& Shyu, Chi-Ren…[et al.]. 2014. Novel Approach for Coexpression Analysis of E2F1–3 and MYC Target Genes in Chronic Myelogenous Leukemia. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-472491
Modern Language Association (MLA)
Wang, Fengfeng…[et al.]. Novel Approach for Coexpression Analysis of E2F1–3 and MYC Target Genes in Chronic Myelogenous Leukemia. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-472491
American Medical Association (AMA)
Wang, Fengfeng& Chan, Lawrence W. C.& Cho, William Chi-Shing& Tang, Petrus& Yu, Jun& Shyu, Chi-Ren…[et al.]. Novel Approach for Coexpression Analysis of E2F1–3 and MYC Target Genes in Chronic Myelogenous Leukemia. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-472491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472491