α-Mangostin from Cratoxylum arborescens (Vahl) Blume Demonstrates Anti-Ulcerogenic Property : A Mechanistic Study
Joint Authors
Mohamed Elhassan Taha, Manal
Abdel Wahab, Siddig Ibrahim
Loke Fai, Mun
Mohan, Syam
Hashim, Najihah Mohd
Vadivelu, Jamunarani
Abdulla, Mahmood Ameen
Hadi, A. Hamid A.
Sidahmed, Heyam M. A.
Yahayu, Maizatulakmal
Rahmani, Mawardi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cratoxylum arborescens (Vahl) Blume is an Asian herbal medicine with versatile ethnobiological properties including treatment of gastric ulcer.
This study evaluated the antiulcerogenic mechanism(s) of α-mangostin (AM) in a rat model of ulcer.
AM is a prenylated xanthone derived through biologically guided fractionation of C.
arborescens.
Rats were orally pretreated with AM and subsequently exposed to acute gastric lesions induced by ethanol.
Following treatment, ulcer index, gastric juice acidity, mucus content, histological and immunohistochemical analyses, glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO), and nonprotein sulfhydryl groups (NP-SH) were evaluated.
The anti-Helicobacter pylori, cyclooxygenase-2 (COX-2) inhibitory effect, and antioxidant activity of AM were also investigated in vitro.
AM (10 and 30 mg/kg) inhibited significantly (P<0.05) ethanol-induced gastric lesions by 66.04% and 74.39 %, respectively.
The compound induces the expression of Hsp70, restores GSH levels, decreases lipid peroxidation, and inhibits COX-2 activity.
The minimum inhibitory concentration (MIC) of AM showed an effective in vitro anti-H.
pylori activity.
The efficacy of the AM was accomplished safely without presenting any toxicological parameters.
The results of the present study indicate that the antioxidant properties and the potent anti-H.
pylori, in addition to activation of Hsp70 protein, may contribute to the gastroprotective activity of α-mangostin.
American Psychological Association (APA)
Sidahmed, Heyam M. A.& Abdel Wahab, Siddig Ibrahim& Mohan, Syam& Abdulla, Mahmood Ameen& Mohamed Elhassan Taha, Manal& Hashim, Najihah Mohd…[et al.]. 2013. α-Mangostin from Cratoxylum arborescens (Vahl) Blume Demonstrates Anti-Ulcerogenic Property : A Mechanistic Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-472577
Modern Language Association (MLA)
Sidahmed, Heyam M. A.…[et al.]. α-Mangostin from Cratoxylum arborescens (Vahl) Blume Demonstrates Anti-Ulcerogenic Property : A Mechanistic Study. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-472577
American Medical Association (AMA)
Sidahmed, Heyam M. A.& Abdel Wahab, Siddig Ibrahim& Mohan, Syam& Abdulla, Mahmood Ameen& Mohamed Elhassan Taha, Manal& Hashim, Najihah Mohd…[et al.]. α-Mangostin from Cratoxylum arborescens (Vahl) Blume Demonstrates Anti-Ulcerogenic Property : A Mechanistic Study. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-472577
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472577