The Mammary Gland Microenvironment Directs Progenitor Cell Fate In Vivo
Joint Authors
Bussard, Karen M.
Smith, Gilbert H.
Source
International Journal of Cell Biology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The mammary gland is a unique organ that continually undergoes postnatal developmental changes.
In mice, the mammary gland is formed via signals from terminal end buds, which direct ductal growth and elongation.
Intriguingly, it is likely that the entire cellular repertoire of the mammary gland is formed from a single antecedent cell.
Furthermore, in order to produce progeny of varied lineages (e.g., luminal and myoepithelial cells), signals from the local tissue microenvironment influence mammary stem/progenitor cell fate.
Data have shown that cells from the mammary gland microenvironment reprogram adult somatic cells from other organs (testes, nerve) into cells that produce milk and express mammary epithelial cell proteins.
Similar results were found for human tumorigenic epithelial carcinoma cells.
Presently, it is unclear how the deterministic power of the mammary gland microenvironment controls epithelial cell fate.
Regardless, signals generated by the microenvironment have a profound influence on progenitor cell differentiation in vivo.
American Psychological Association (APA)
Bussard, Karen M.& Smith, Gilbert H.. 2011. The Mammary Gland Microenvironment Directs Progenitor Cell Fate In Vivo. International Journal of Cell Biology،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-472642
Modern Language Association (MLA)
Bussard, Karen M.& Smith, Gilbert H.. The Mammary Gland Microenvironment Directs Progenitor Cell Fate In Vivo. International Journal of Cell Biology No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-472642
American Medical Association (AMA)
Bussard, Karen M.& Smith, Gilbert H.. The Mammary Gland Microenvironment Directs Progenitor Cell Fate In Vivo. International Journal of Cell Biology. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-472642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472642