Bidirectional Microglia-Neuron Communication in the Healthy Brain
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Unlike other resident neural cells that are of neuroectodermal origin, microglia are resident neural cells of mesodermal origin.
Traditionally recognized for their immune functions during disease, new roles are being attributed to these cells in the development and maintenance of the central nervous system (CNS) including specific communication with neurons.
In this review, we highlight some of the recent findings on the bidirectional interaction between neurons and microglia.
We discuss these interactions along two lines.
First, we review data that suggest that microglial activity is modulated by neuronal signals, focusing on evidence that (i) neurons are capable of regulating microglial activation state and influence basal microglial activities; (ii) classic neurotransmitters affect microglial behavior; (iii) chemotactic signals attract microglia during acute neuronal injury.
Next, we discuss some of the recent data on how microglia signal to neurons.
Signaling mechanisms include (i) direct physical contact of microglial processes with neuronal elements; (ii) microglial regulation of neuronal synapse and circuit by fractalkine, complement, and DAP12 signaling.
In addition, we discuss the use of microglial depletion strategies in studying the role of microglia in neuronal development and synaptic physiology.
Deciphering the mechanisms of bidirectional microglial-neuronal communication provides novel insights in understanding microglial function in both the healthy and diseased brain.
American Psychological Association (APA)
Eyo, Ukpong B.& Wu, Long-Jun. 2013. Bidirectional Microglia-Neuron Communication in the Healthy Brain. Neural Plasticity،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-472982
Modern Language Association (MLA)
Eyo, Ukpong B.& Wu, Long-Jun. Bidirectional Microglia-Neuron Communication in the Healthy Brain. Neural Plasticity No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-472982
American Medical Association (AMA)
Eyo, Ukpong B.& Wu, Long-Jun. Bidirectional Microglia-Neuron Communication in the Healthy Brain. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-472982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472982