Polymorphisms in α- and β-Adrenergic Receptor Genes, Hypertension, and Obstructive Sleep Apnea : The Skaraborg Sleep Study
Joint Authors
von Wowern, Fredrik
Grote, Ludger
Groop, Leif
Lindblad, Ulf
Bengtsson Boström, Kristina
Hedner, Jan
Råstam, Lennart
Melander, Olle
Source
International Journal of Hypertension
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The sympathetic nervous system and the adrenergic receptors play an important role in regulation of blood pressure.
This study explored the associations between functional polymorphisms of the α2B-, β1-, and β2-adrenergic receptor genes and obstructive sleep apnea (OSA) in hypertensive patients and hypertension in patients with OSA in a populationbased sample of 157 hypertensive patients and 181 healthy control subjects.
Only the Arg389Gly polymorphism of the β1-adrenergic receptor gene was associated with increased risk for mild OSA in hypertensive patients (Arg/Arg versus Gly/Arg/Gly/Gly, 2.1, 95% CI, 1.02–4.7).
Hypertensive men carrying the Arg389Arg genotype had higher crude and age-adjusted AHI than carriers of the Arg389Gly/Gly389Gly genotypes.
When adjusted also for BMI this difference became borderline significant.
This difference was not observed in women.
The risk of hypertension in mild OSA was associated with increasing number of Arg-alleles (Arg/Arg OR 5.4, 95% CI 1.4–21.2).
American Psychological Association (APA)
Bengtsson Boström, Kristina& Hedner, Jan& Grote, Ludger& Melander, Olle& von Wowern, Fredrik& Råstam, Lennart…[et al.]. 2010. Polymorphisms in α- and β-Adrenergic Receptor Genes, Hypertension, and Obstructive Sleep Apnea : The Skaraborg Sleep Study. International Journal of Hypertension،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-473126
Modern Language Association (MLA)
Bengtsson Boström, Kristina…[et al.]. Polymorphisms in α- and β-Adrenergic Receptor Genes, Hypertension, and Obstructive Sleep Apnea : The Skaraborg Sleep Study. International Journal of Hypertension No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-473126
American Medical Association (AMA)
Bengtsson Boström, Kristina& Hedner, Jan& Grote, Ludger& Melander, Olle& von Wowern, Fredrik& Råstam, Lennart…[et al.]. Polymorphisms in α- and β-Adrenergic Receptor Genes, Hypertension, and Obstructive Sleep Apnea : The Skaraborg Sleep Study. International Journal of Hypertension. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-473126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473126