Smouldering Malignant Melanoma and Metastatic Dormancy : An Update and Review
Joint Authors
Quatresooz, Pascale
Piérard, Gérald E.
Reginster, Marie-Annick
Piérard-Franchimont, Claudine
Source
Dermatology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The fund of knowledge regarding the versatility of presentation of MM metastases is still quite incomplete.
The recent literature pertaining to the current understanding of the mechanisms underlying two special features of MM metastasis is reviewed.
On the one hand, a long disease-free interval (MM dormancy) may occur before the surge of overt metastases.
On the other hand, the so-called MM smouldering phenomenon refers to the condition where regional metastases wax and wane for long periods of time on restricted skin regions.
It is important to emphasize that local micrometastases often predict sentinel lymph node involvement but may not reflect progression of the primary MM to full-blown visceral metastatic competence.
It is likely that a combination of factors impacts the versatile MM metastasic progression.
Among the main factors, one has to mention the phenotypic heterogeneity and variability in the phenotype of MM cells, the presence of MM stem cells and MM cells engaged in an amplification proliferation pool, as well as the host immune response, and possibly the induction of a particular stromal structure and vascularity.
American Psychological Association (APA)
Piérard, Gérald E.& Piérard-Franchimont, Claudine& Reginster, Marie-Annick& Quatresooz, Pascale. 2011. Smouldering Malignant Melanoma and Metastatic Dormancy : An Update and Review. Dermatology Research and Practice،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-473375
Modern Language Association (MLA)
Piérard, Gérald E.…[et al.]. Smouldering Malignant Melanoma and Metastatic Dormancy : An Update and Review. Dermatology Research and Practice No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-473375
American Medical Association (AMA)
Piérard, Gérald E.& Piérard-Franchimont, Claudine& Reginster, Marie-Annick& Quatresooz, Pascale. Smouldering Malignant Melanoma and Metastatic Dormancy : An Update and Review. Dermatology Research and Practice. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-473375
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473375