Tumor Suppressor Gene-Based Nanotherapy : From Test Tube to the Clinic
Joint Authors
Miyamoto, Shinya
Shanker, Manish
Roth, Jack A.
Branch, Cynthia D.
Jin, Jiankang
Grimm, Elizabeth A.
Ramesh, Rajagopal
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cancer is a major health problem in the world.
Advances made in cancer therapy have improved the survival of patients in certain types of cancer.
However, the overall five-year survival has not significantly improved in the majority of cancer types.
Major challenges encountered in having effective cancer therapy are development of drug resistance by the tumor cells, nonspecific cytotoxicity, and inability to affect metastatic tumors by the chemodrugs.
Overcoming these challenges requires development and testing of novel therapies.
One attractive cancer therapeutic approach is cancer gene therapy.
Several laboratories including the authors' laboratory have been investigating nonviral formulations for delivering therapeutic genes as a mode for effective cancer therapy.
In this paper the authors will summarize their experience in the development and testing of a cationic lipid-based nanocarrier formulation and the results from their preclinical studies leading to a Phase I clinical trial for nonsmall cell lung cancer.
Their nanocarrier formulation containing therapeutic genes such as tumor suppressor genes when administered intravenously effectively controls metastatic tumor growth.
Additional Phase I clinical trials based on the results of their nanocarrier formulation have been initiated or proposed for treatment of cancer of the breast, ovary, pancreas, and metastatic melanoma, and will be discussed.
American Psychological Association (APA)
Shanker, Manish& Jin, Jiankang& Branch, Cynthia D.& Miyamoto, Shinya& Grimm, Elizabeth A.& Roth, Jack A.…[et al.]. 2011. Tumor Suppressor Gene-Based Nanotherapy : From Test Tube to the Clinic. Journal of Drug Delivery،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-473759
Modern Language Association (MLA)
Shanker, Manish…[et al.]. Tumor Suppressor Gene-Based Nanotherapy : From Test Tube to the Clinic. Journal of Drug Delivery No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-473759
American Medical Association (AMA)
Shanker, Manish& Jin, Jiankang& Branch, Cynthia D.& Miyamoto, Shinya& Grimm, Elizabeth A.& Roth, Jack A.…[et al.]. Tumor Suppressor Gene-Based Nanotherapy : From Test Tube to the Clinic. Journal of Drug Delivery. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-473759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473759