Anti-TNF-α Therapies in Systemic Lupus Erythematosus
Joint Authors
Yu, Xue-Qing
Yang, Xiao
Zhu, Lang-Jing
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Tumor necrosis factor (TNF)-α is not just a proinflammatory cytokine.
It has also been proposed to be an immunoregulatory molecule that can alter the balance of T regulatory cells.
Anti-TNF-α therapies have been provided clinical benefit to many patients and introduced for treating moderate to severe rheumatoid arthritis, Crohn's disease, and other chronic inflammatory disorders.
However, their use also is accompanied by new or aggravated forms of autoimmunity, such as formation of autoantibodies, including antinuclear antibodies (ANAs), antidouble-stranded DNA (dsDNA) antibodies, and anticardiolipin antibodies (ACL).
Systemic lupus erythematosus (SLE) is a disease with autoimmune disturbance and inflammatory damage.
The role of TNF-α in human SLE is controversial.
Here we review the role of TNF-α in the pathophysiological processes of SLE and the likely effects of blocking TNF-α in treatment of SLE.
American Psychological Association (APA)
Zhu, Lang-Jing& Yang, Xiao& Yu, Xue-Qing. 2010. Anti-TNF-α Therapies in Systemic Lupus Erythematosus. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-473766
Modern Language Association (MLA)
Zhu, Lang-Jing…[et al.]. Anti-TNF-α Therapies in Systemic Lupus Erythematosus. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-473766
American Medical Association (AMA)
Zhu, Lang-Jing& Yang, Xiao& Yu, Xue-Qing. Anti-TNF-α Therapies in Systemic Lupus Erythematosus. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-473766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473766