Soluble IL-2 Receptor : A Biomarker for Assessing Myositis Activity
Joint Authors
Ristori, Jean-Michel
Souteyrand, Pierre
Clavelou, Pierre
Schmidt, Jeannot
Tridon, Arlette
Tournadre, Anne
Soubrier, Martin
Dubost, Jean-Jacques
Ruivard, Marc
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To evaluate the clinical significance of serum soluble IL-2R (sIL-2R) in inflammatory myopathies.
Methods.
Serum sIL-2R and CK levels were determined in 27 patients with IM during periods of disease exacerbation and inactive disease and were compared to 20 healthy controls and 23 controls with noninflammatory elevated CK.
The performance of sIL-2R and CK tests for assessing disease activity was compared.
Results.
sIL-2R levels were increased in patients with IM.
Significantly higher sIL-2R levels were detected in patients with disease exacerbation than in patients with inactive disease.
In patients with IM, the sIL-2R levels correlated with the CK levels.
Based on ROC analysis, diagnostic accuracy of sIL-2R and CK tests for disease activity was similar.
However, when the CK threshold was defined by the upper limit of the normal, the specificity for the CK test dropped to 58%.
Conclusion.
Serum sIL-2R level could be useful to distinguish disease exacerbation from damage in IM, especially in patients with persistent elevated CK levels when a clinical muscular worsening is noted.
For discrimination of the disease activity, CK testing requires the use of a different threshold than the upper limit of the normal.
American Psychological Association (APA)
Tournadre, Anne& Dubost, Jean-Jacques& Soubrier, Martin& Ruivard, Marc& Souteyrand, Pierre& Schmidt, Jeannot…[et al.]. 2014. Soluble IL-2 Receptor : A Biomarker for Assessing Myositis Activity. Disease Markers،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-474244
Modern Language Association (MLA)
Tournadre, Anne…[et al.]. Soluble IL-2 Receptor : A Biomarker for Assessing Myositis Activity. Disease Markers No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-474244
American Medical Association (AMA)
Tournadre, Anne& Dubost, Jean-Jacques& Soubrier, Martin& Ruivard, Marc& Souteyrand, Pierre& Schmidt, Jeannot…[et al.]. Soluble IL-2 Receptor : A Biomarker for Assessing Myositis Activity. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-474244
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474244