Interleukin-6 Contributes to Age-Related Alteration of Cytokine Production by Macrophages

Joint Authors

Gomez, Christian R.
Nomellini, Vanessa
Kovacs, Elizabeth J.
Palmer, Jessica L.
Ramirez, Luis
Karavitis, John
Faunce, Douglas E.

Source

Mediators of Inflammation

Issue

Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2010-07-07

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases

Abstract EN

Here, we studied in vitro cytokine production by splenic macrophages obtained from young and aged BALB/c wild type (WT) and IL-6 knockout (IL-6 KO) mice.

Relative to macrophages obtained from young WT mice given lipopolysaccharide (LPS), those from aged WT mice had decreased production of proinflammatory cytokines.

In contrast, when compared to macrophages from young IL-6 KO mice, LPS stimulation yielded higher levels of these cytokines by cells from aged IL-6 KO mice.

Aging or IL-6 deficiency did not affected the percentage of F4/80+ macrophages, or the surface expression of Toll-like receptor 4 (TLR4) and components of the IL-6 receptor.

Overall, our results indicate that IL-6 plays a role in regulating the age-related defects in macrophages through alteration of proinflammatory cytokines, adding to the complexity of IL-6-mediated impairment of immune cell function with increasing age.

American Psychological Association (APA)

Gomez, Christian R.& Karavitis, John& Palmer, Jessica L.& Faunce, Douglas E.& Ramirez, Luis& Nomellini, Vanessa…[et al.]. 2010. Interleukin-6 Contributes to Age-Related Alteration of Cytokine Production by Macrophages. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-474494

Modern Language Association (MLA)

Gomez, Christian R.…[et al.]. Interleukin-6 Contributes to Age-Related Alteration of Cytokine Production by Macrophages. Mediators of Inflammation No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-474494

American Medical Association (AMA)

Gomez, Christian R.& Karavitis, John& Palmer, Jessica L.& Faunce, Douglas E.& Ramirez, Luis& Nomellini, Vanessa…[et al.]. Interleukin-6 Contributes to Age-Related Alteration of Cytokine Production by Macrophages. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-474494

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-474494