Interleukin-6 Contributes to Age-Related Alteration of Cytokine Production by Macrophages
Joint Authors
Gomez, Christian R.
Nomellini, Vanessa
Kovacs, Elizabeth J.
Palmer, Jessica L.
Ramirez, Luis
Karavitis, John
Faunce, Douglas E.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Here, we studied in vitro cytokine production by splenic macrophages obtained from young and aged BALB/c wild type (WT) and IL-6 knockout (IL-6 KO) mice.
Relative to macrophages obtained from young WT mice given lipopolysaccharide (LPS), those from aged WT mice had decreased production of proinflammatory cytokines.
In contrast, when compared to macrophages from young IL-6 KO mice, LPS stimulation yielded higher levels of these cytokines by cells from aged IL-6 KO mice.
Aging or IL-6 deficiency did not affected the percentage of F4/80+ macrophages, or the surface expression of Toll-like receptor 4 (TLR4) and components of the IL-6 receptor.
Overall, our results indicate that IL-6 plays a role in regulating the age-related defects in macrophages through alteration of proinflammatory cytokines, adding to the complexity of IL-6-mediated impairment of immune cell function with increasing age.
American Psychological Association (APA)
Gomez, Christian R.& Karavitis, John& Palmer, Jessica L.& Faunce, Douglas E.& Ramirez, Luis& Nomellini, Vanessa…[et al.]. 2010. Interleukin-6 Contributes to Age-Related Alteration of Cytokine Production by Macrophages. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-474494
Modern Language Association (MLA)
Gomez, Christian R.…[et al.]. Interleukin-6 Contributes to Age-Related Alteration of Cytokine Production by Macrophages. Mediators of Inflammation No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-474494
American Medical Association (AMA)
Gomez, Christian R.& Karavitis, John& Palmer, Jessica L.& Faunce, Douglas E.& Ramirez, Luis& Nomellini, Vanessa…[et al.]. Interleukin-6 Contributes to Age-Related Alteration of Cytokine Production by Macrophages. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-474494
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474494