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Whipple’s Disease : Our Own Experience and Review of the Literature
Joint Authors
Tomš, Jan
Kopacova, Marcela
Rejchrt, Stanislav
Bures, Jan
Tachecí, Ilja
Bártová, Jolana
Douda, Tomáš
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Whipple’s disease is a chronic infectious systemic disease caused by the bacterium Tropheryma whipplei.
Nondeforming arthritis is frequently an initial complaint.
Gastrointestinal and general symptoms include marked diarrhoea (with serious malabsorption), abdominal pain, prominent weight loss, and low-grade fever.
Possible neurologic symptoms (up to 20%) might be associated with worse prognosis.
Diagnosis is based on the clinical picture and small intestinal histology revealing foamy macrophages containing periodic-acid-Schiff- (PAS-) positive material.
Long-term (up to one year) antibiotic therapy provides a favourable outcome in the vast majority of cases.
This paper provides review of the literature and an analysis of our 5 patients recorded within a 20-year period at a tertiary gastroenterology centre.
Patients were treated using i.v.
penicillin G or amoxicillin-clavulanic acid + i.v.
gentamicin for two weeks, followed by p.o.
doxycycline (100 mg per day) plus p.o.
salazopyrine (3 g per day) for 1 year.
Full remission was achieved in all our patients.
American Psychological Association (APA)
Bures, Jan& Kopacova, Marcela& Douda, Tomáš& Bártová, Jolana& Tomš, Jan& Rejchrt, Stanislav…[et al.]. 2013. Whipple’s Disease : Our Own Experience and Review of the Literature. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-474711
Modern Language Association (MLA)
Bures, Jan…[et al.]. Whipple’s Disease : Our Own Experience and Review of the Literature. Gastroenterology Research and Practice No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-474711
American Medical Association (AMA)
Bures, Jan& Kopacova, Marcela& Douda, Tomáš& Bártová, Jolana& Tomš, Jan& Rejchrt, Stanislav…[et al.]. Whipple’s Disease : Our Own Experience and Review of the Literature. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-474711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474711