BDKRB2 +9−9 Polymorphism Is Associated with Higher Risk for Diabetes Mellitus in the Brazilian General Population
Joint Authors
Krieger, José Eduardo
Pereira, Alexandre C.
Mill, José Geraldo
Coelho, George L. L. M.
Alvim, Rafael de Oliveira
Santos, Paulo Caleb Junior Lima
Nascimento, Raimundo M.
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-29
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Some mechanisms have been proposed to explain the role of bradykinin on glucose homeostasis and some studies reported that the BDKRB2 +9/−9 polymorphism was associated to the transcriptional activity of the receptor.
In this scenario, the main aim of this study was to evaluate the association of the BDKRB2 +9/−9 polymorphism with diabetes mellitus risk in the Brazilian general population.
This study included 1,032 subjects of the general urban population.
Anthropometrical, blood pressure, biochemical, and genotype analyses for the BDKRB2 +9/−9 bp insertion/deletion polymorphism were performed.
Individuals carrying +9/+9 or +9/−9 genotypes had higher glucose values (84.5 mg/dL versus 80.6 mg/dL, resp.) and higher frequency of diabetes mellitus (7.6% versus 3.6%, resp.) compared to individuals carrying −9/−9, adjusting for age and gender.
In addition, higher diabetes mellitus risk was associated to presence of the +9/+9 or +9/−9 genotypes (OR = 1.91; 95% CI = 1.09–4.19; P=0.03).
Our data suggest that the BDKRB2 +9/-9 polymorphism may act as a genetic modulator of glucose homeostasis.
It was previously associated to insulin sensitivity, glucose uptake, and insulin secretion, and, in this study, data suggest that the polymorphism may increase susceptibility to chronic metabolic conditions such as diabetes in the Brazilian population.
American Psychological Association (APA)
Alvim, Rafael de Oliveira& Santos, Paulo Caleb Junior Lima& Nascimento, Raimundo M.& Coelho, George L. L. M.& Mill, José Geraldo& Krieger, José Eduardo…[et al.]. 2012. BDKRB2 +9−9 Polymorphism Is Associated with Higher Risk for Diabetes Mellitus in the Brazilian General Population. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-474868
Modern Language Association (MLA)
Alvim, Rafael de Oliveira…[et al.]. BDKRB2 +9−9 Polymorphism Is Associated with Higher Risk for Diabetes Mellitus in the Brazilian General Population. Experimental Diabetes Research No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-474868
American Medical Association (AMA)
Alvim, Rafael de Oliveira& Santos, Paulo Caleb Junior Lima& Nascimento, Raimundo M.& Coelho, George L. L. M.& Mill, José Geraldo& Krieger, José Eduardo…[et al.]. BDKRB2 +9−9 Polymorphism Is Associated with Higher Risk for Diabetes Mellitus in the Brazilian General Population. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-474868
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-474868