Polymorphisms in Tumour Necrosis Factor Alpha (TNFα) Gene in Patients with Acute Pancreatitis
Joint Authors
Özhan, Gül
Alpertunga, Buket
Yanar, Hakan T.
Ertekin, Cemalettin
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Proinflammatory cytokines, such as tumour necrosis factor α (TNFα), play fundamental roles in the pathogenesis of acute pancreatitis (AP).
The aim of this study was to determine if polymorphisms in the TNFα gene are associated with AP.
Two polymorphisms located in the promoter region (positions −308 and −238) in TNFα gene were determined using polymerase chain reaction- (PCR-) restriction fragment length polymorphism (RFLP) methods in 103 patients with AP and 92 healthy controls.
Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using logistic regression analysis adjusted for age, sex, BMI and smoking.
The frequencies of TNFα polymorphisms were both similar in patients with mild or severe pancreatitis, so were in pancreatitis patients and in controls.
We suggest that both SNPs of TNFα are not genetic risk factor for AP susceptibility (OR = 1.63; 95% CI: 1.13−4.01 for TNFα−308 and OR = 0.86; 95% CI: 0.75−1.77 for TNFα−238).
American Psychological Association (APA)
Özhan, Gül& Yanar, Hakan T.& Ertekin, Cemalettin& Alpertunga, Buket. 2010. Polymorphisms in Tumour Necrosis Factor Alpha (TNFα) Gene in Patients with Acute Pancreatitis. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-475154
Modern Language Association (MLA)
Özhan, Gül…[et al.]. Polymorphisms in Tumour Necrosis Factor Alpha (TNFα) Gene in Patients with Acute Pancreatitis. Mediators of Inflammation No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-475154
American Medical Association (AMA)
Özhan, Gül& Yanar, Hakan T.& Ertekin, Cemalettin& Alpertunga, Buket. Polymorphisms in Tumour Necrosis Factor Alpha (TNFα) Gene in Patients with Acute Pancreatitis. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-475154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475154