Peroxisome Proliferator-Activated Receptorα Agonists Differentially Regulate Inhibitor of DNA Binding Expression in Rodents and Human Cells
Joint Authors
Quirós, Yolanda
Álvarez-Millán, Juan José
Muñoz-Mingarro, Dolores
Acero, Nuria
Bocos, Carlos
Corton, J. Christopher
Herrera, Emilio
González, María del Carmen
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Inhibitor of DNA binding (Id2) is a helix-loop-helix (HLH) transcription factor that participates in cell differentiation and proliferation.
Id2 has been linked to the development of cardiovascular diseases since thiazolidinediones, antidiabetic agents and peroxisome proliferator-activated receptor (PPAR) gamma agonists, have been reported to diminish Id2 expression in human cells.
We hypothesized that PPARα activators may also alter Id2 expression.
Fenofibrate diminished hepatic Id2 expression in both late pregnant and unmated rats.
In 24 hour fasted rats, Id2 expression was decreased under conditions known to activate PPARα.
In order to determine whether the fibrate effects were mediated by PPARα, wild-type mice and PPARα-null mice were treated with Wy-14,643 (WY).
WY reduced Id2 expression in wild-type mice without an effect in PPARα-null mice.
In contrast, fenofibrate induced Id2 expression after 24 hours of treatment in human hepatocarcinoma cells (HepG2).
MK-886, a PPARα antagonist, did not block fenofibrate-induced activation of Id2 expression, suggesting a PPARα-independent effect was involved.
These findings confirm that Id2 is a gene responsive to PPARα agonists.
Like other genes (apolipoprotein A-I, apolipoprotein A-V), the opposite directional transcriptional effect in rodents and a human cell line further emphasizes that PPARα agonists have different effects in rodents and humans.
American Psychological Association (APA)
González, María del Carmen& Corton, J. Christopher& Acero, Nuria& Muñoz-Mingarro, Dolores& Quirós, Yolanda& Álvarez-Millán, Juan José…[et al.]. 2012. Peroxisome Proliferator-Activated Receptorα Agonists Differentially Regulate Inhibitor of DNA Binding Expression in Rodents and Human Cells. PPAR Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-475211
Modern Language Association (MLA)
González, María del Carmen…[et al.]. Peroxisome Proliferator-Activated Receptorα Agonists Differentially Regulate Inhibitor of DNA Binding Expression in Rodents and Human Cells. PPAR Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-475211
American Medical Association (AMA)
González, María del Carmen& Corton, J. Christopher& Acero, Nuria& Muñoz-Mingarro, Dolores& Quirós, Yolanda& Álvarez-Millán, Juan José…[et al.]. Peroxisome Proliferator-Activated Receptorα Agonists Differentially Regulate Inhibitor of DNA Binding Expression in Rodents and Human Cells. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-475211
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475211