Effects of PPARγ Ligands on Leukemia
Joint Authors
Andreeff, Michael
Konopleva, Marina
Ohsaka, Akimichi
Tabe, Yoko
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RARs), members of the nuclear receptor superfamily, are transcription factors that regulate a variety of important cellular functions.
PPARs form heterodimers retinoid X receptor (RXR), an obligate heterodimeric partner for other nuclear receptors.
Several novel links between retinoid metabolism and PPAR responses have been identified, and activation of PPAR/RXR expression has been shown to increase response to retinoids.
PPARγ has emerged as a key regulator of cell growth and survival, whose activity is modulated by a number of synthetic and natural ligands.
While clinical trials in cancer patients with thiazolidinediones (TZD) have been disappointing, novel structurally different PPARγ ligands, including triterpenoids, have entered clinical arena as therapeutic agents for epithelial and hematopoietic malignancies.
Here we shall review the antitumor advances of PPARγ, alone and in combination with RARα ligands in control of cell proliferation, differentiation, and apoptosis and their potential therapeutic applications in hematological malignancies.
American Psychological Association (APA)
Tabe, Yoko& Konopleva, Marina& Andreeff, Michael& Ohsaka, Akimichi. 2012. Effects of PPARγ Ligands on Leukemia. PPAR Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-475224
Modern Language Association (MLA)
Tabe, Yoko…[et al.]. Effects of PPARγ Ligands on Leukemia. PPAR Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-475224
American Medical Association (AMA)
Tabe, Yoko& Konopleva, Marina& Andreeff, Michael& Ohsaka, Akimichi. Effects of PPARγ Ligands on Leukemia. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-475224
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475224