A 3’UTR Polymorphism of IL-6R Is Associated with Chinese Pediatric Tuberculosis
Joint Authors
Wu, Xi-rong
Tian, Jian-ling
Qi, Hui
Sun, Lin
Yin, Qing-qin
Xiao, Jing
Shen, Chen
Shen, A-dong
Han, Rui
Jiao, Wei-wei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
IL-6 is a proinflammatory cytokine that plays a critical role in host defense against tuberculosis (TB).
Genetic polymorphisms of IL-6 and its receptor IL-6R had been discussed in adult TB recently.
However, their role in pediatric TB is still unclear.
Due to the obvious differences in TB pathophysiology in children, which may also reflect differences in genetic background, further association studies in pediatric populations are needed.
Methods.
A case-control study was carried out in a Chinese pediatric population including 353 TB patients and 400 healthy controls.
Tag-SNPs of IL-6 and IL-6R genes were selected by Haploview software, genotyped using MassArray, and analyzed statistically.
Results.
One polymorphism, rs2229238, in the 3’UTR region of IL-6R was observed to be associated with increased resistance to TB (adjusted P = 0.03).
The rs2229238 T allele contributed to a reduced risk to TB in recessive heritable model (OR, 0.53; 95% CI, 0.35–0.78).
Conclusions.
By tag-SNP genotyping based case-control study, we identified a genetic polymorphism in the IL-6R 3’UTR that regulates host resistance to pediatric TB in a Chinese population.
American Psychological Association (APA)
Shen, Chen& Qi, Hui& Sun, Lin& Xiao, Jing& Yin, Qing-qin& Jiao, Wei-wei…[et al.]. 2014. A 3’UTR Polymorphism of IL-6R Is Associated with Chinese Pediatric Tuberculosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-475235
Modern Language Association (MLA)
Shen, Chen…[et al.]. A 3’UTR Polymorphism of IL-6R Is Associated with Chinese Pediatric Tuberculosis. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-475235
American Medical Association (AMA)
Shen, Chen& Qi, Hui& Sun, Lin& Xiao, Jing& Yin, Qing-qin& Jiao, Wei-wei…[et al.]. A 3’UTR Polymorphism of IL-6R Is Associated with Chinese Pediatric Tuberculosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-475235
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475235