Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin
Joint Authors
Dixon, Jeremy
George, Eric M.
Granger, Joey P.
Palei, Ana C.
Colson, Drew
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
One of the most prevalent complications of pregnancy is preeclampsia, a hypertensive disorder which is a leading cause of maternal and perinatal morbidity and premature birth with no effective pharmacological intervention.
While the underlying cause is unclear, it is believed that placental ischemia/hypoxia induces the release of factors into the maternal vasculature and lead to widespread maternal endothelial dysfunction.
Recently, HO-1 has been shown to downregulate two of these factors, reactive oxygen species and sFlt-1, and we have reported that HO-1 induction attenuates many of the pathological factors of placental ischemia experimentally.
Here, we have examined the direct effect of HO-1 and its bioactive metabolites on hypoxia-induced changes in superoxide and sFlt-1 in placental vascular explants and showed that HO-1 and its metabolites attenuate the production of both factors in this system.
These findings suggest that the HO-1 pathway may be a promising therapeutic approach for the treatment of preeclampsia.
American Psychological Association (APA)
George, Eric M.& Colson, Drew& Dixon, Jeremy& Palei, Ana C.& Granger, Joey P.. 2011. Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-475439
Modern Language Association (MLA)
George, Eric M.…[et al.]. Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin. International Journal of Hypertension No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-475439
American Medical Association (AMA)
George, Eric M.& Colson, Drew& Dixon, Jeremy& Palei, Ana C.& Granger, Joey P.. Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin. International Journal of Hypertension. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-475439
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-475439