The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection
Joint Authors
Mohamadkhani, Ashraf
Tayebi, Sirous
Source
Hepatitis Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background and Aims.
TNF-α -308 allele promoter polymorphism has been known to be a potential prognostic factor in patients with chronic HBV infection.
We tried to determine how TNF-α -308 allele promoter polymorphism would affect the prognosis in patients with chronic HBV infection.
Methods.
We searched MEDLINE, EMBASE, and reference lists of relevant review articles related to the association between “TNF-α G-308A promoter polymorphism” with “chronic HBV infection”.
We only focused on searching -308 locus in published studies.
We reviewed 21 original articles about TNF-α -308 allele polymorphism and its effect on prognosis in patients with chronic HBV infection and discussed the results.
Results.
conflicting results were observed.
The results were divided into 3 groups including neutral, negative, and positive associations between TNF-α -308 allele polymorphism and prognosis in patients with chronic HBV infection.
We summarized the primary data as a table.
Conclusions.
Authors concluded that although there is an upward trend in evidence to claim that there is a positive relation between TNF-α G-308A promoter polymorphisms and resolution of chronic HBV infection, due to many biases and limitations observed in reviewed studies, an organized well-designed study is needed for clarifying the real association.
American Psychological Association (APA)
Tayebi, Sirous& Mohamadkhani, Ashraf. 2012. The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection. Hepatitis Research and Treatment،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-476042
Modern Language Association (MLA)
Tayebi, Sirous& Mohamadkhani, Ashraf. The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection. Hepatitis Research and Treatment No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-476042
American Medical Association (AMA)
Tayebi, Sirous& Mohamadkhani, Ashraf. The TNF-α -308 Promoter Gene Polymorphism and Chronic HBV Infection. Hepatitis Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-476042
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476042