Association between Preoperative Plasma sRAGE Levels and Recovery from Cardiac Surgery
Joint Authors
Burke-Gaffney, Anne
Quinlan, Gregory J.
Evans, Timothy W.
Hector, Lauren R.
Creagh-Brown, Benedict C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The receptor for advanced glycation end products (RAGE) is an inflammation-perpetuating receptor, and soluble RAGE (sRAGE) is a marker of cellular RAGE expression.
This study investigated whether raised plasma levels prior to surgery of sRAGE or S100A8/A9 (a RAGE ligand) were associated with longer duration of hospital care in patients undergoing cardiac surgery necessitating cardiopulmonary bypass.
Methods.
Patients (n=130) undergoing elective cardiac surgery were enrolled prospectively.
Plasma sRAGE and S100A8/A9 concentrations were measured before and 2 h after surgery.
Results.
Preoperative plasma sRAGE increased significantly (P<0.0001) from 1.06 ng/mL (IQR, 0.72–1.76) to 1.93 ng/mL (IQR, 1.14–2.63) 2 h postoperatively.
Plasma S100A8/9 was also significantly (P<0.0001) higher 2 h postoperatively (2.37 μg/mL, IQR, 1.81–3.05) compared to pre-operative levels (0.41 μg/mL, IQR, 0.2–0.65).
Preoperative sRAGE, but not S100A8/A9, was positively and significantly correlated with duration of critical illness (r=0.3, P=0.0007) and length of hospital stay (LOS; r=0.31, P<0.0005).
Multivariate binary logistic regression showed preoperative sRAGE to be, statistically, an independent predictor of greater than median duration of critical illness (odds ratio 16.6, P=0.014) and to be, statistically, the strongest independent predictor of hospital LOS.
Conclusion.
Higher preoperative plasma sRAGE levels were associated with prolonged duration of care in adults undergoing cardiac surgery requiring cardiopulmonary bypass.
American Psychological Association (APA)
Creagh-Brown, Benedict C.& Quinlan, Gregory J.& Hector, Lauren R.& Evans, Timothy W.& Burke-Gaffney, Anne. 2013. Association between Preoperative Plasma sRAGE Levels and Recovery from Cardiac Surgery. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-476276
Modern Language Association (MLA)
Creagh-Brown, Benedict C.…[et al.]. Association between Preoperative Plasma sRAGE Levels and Recovery from Cardiac Surgery. Mediators of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-476276
American Medical Association (AMA)
Creagh-Brown, Benedict C.& Quinlan, Gregory J.& Hector, Lauren R.& Evans, Timothy W.& Burke-Gaffney, Anne. Association between Preoperative Plasma sRAGE Levels and Recovery from Cardiac Surgery. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-476276
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476276