Targeting Toll-Like Receptors for Treatment of SLE
Joint Authors
Pan, Zi-jian
Farris, A. Darise
Horton, Christopher G.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Toll-like receptors (TLRs) are important innate immune receptors for the identification and clearance of invading pathogens.
Twelve TLRs that recognize various conserved components of microorganisms are currently known.
Among these, the endosomal TLRs 3, 7/8, and 9 recognize dsRNA, ssRNA, and CpG DNA, respectively.
Nucleic acid-sensing TLRs, TLR 7 in particular, have been implicated in systemic lupus erythematosus (SLE) and are thought to exacerbate disease pathology.
Activation of these TLRs results in the production of inflammatory cytokines and type I interferon.
Genome-wide association studies, single nucleotide polymorphism analyses as well as experimental mouse models have provided evidence of TLR signaling involvement in SLE and other autoimmune diseases.
Since activation of these receptor pathways promotes autoimmune phenotypes, inhibitory drugs that target these pathways constitute important new therapeutic strategies for the treatment of systemic autoimmunity.
American Psychological Association (APA)
Horton, Christopher G.& Pan, Zi-jian& Farris, A. Darise. 2010. Targeting Toll-Like Receptors for Treatment of SLE. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-476543
Modern Language Association (MLA)
Horton, Christopher G.…[et al.]. Targeting Toll-Like Receptors for Treatment of SLE. Mediators of Inflammation No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-476543
American Medical Association (AMA)
Horton, Christopher G.& Pan, Zi-jian& Farris, A. Darise. Targeting Toll-Like Receptors for Treatment of SLE. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-476543
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476543