Long-Term Left Ventricular Remodelling in Rat Model of Nonreperfused Myocardial Infarction : Sequential MR Imaging Using a 3T Clinical Scanner
Joint Authors
Franz, Thomas
Meintjes, Ernesta M.
Davies, Neil H.
van der Kouwe, Andre J. W.
Saleh, Muhammad G.
Sharp, Sarah-Kate
Spottiswoode, Bruce S.
Alhamud, Alkathafi
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
To evaluate whether 3T clinical MRI with a small-animal coil and gradient-echo (GE) sequence could be used to characterize long-term left ventricular remodelling (LVR) following nonreperfused myocardial infarction (MI) using semi-automatic segmentation software (SASS) in a rat model.
Materials and Methods.
5 healthy rats were used to validate left ventricular mass (LVM) measured by MRI with postmortem values.
5 sham and 7 infarcted rats were scanned at 2 and 4 weeks after surgery to allow for functional and structural analysis of the heart.
Measurements included ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), and LVM.
Changes in different regions of the heart were quantified using wall thickness analyses.
Results.
LVM validation in healthy rats demonstrated high correlation between MR and postmortem values.
Functional assessment at 4 weeks after MI revealed considerable reduction in EF, increases in ESV, EDV, and LVM, and contractile dysfunction in infarcted and noninfarcted regions.
Conclusion.
Clinical 3T MRI with a small animal coil and GE sequence generated images in a rat heart with adequate signal-to-noise ratio (SNR) for successful semiautomatic segmentation to accurately and rapidly evaluate long-term LVR after MI.
American Psychological Association (APA)
Saleh, Muhammad G.& Sharp, Sarah-Kate& Alhamud, Alkathafi& Spottiswoode, Bruce S.& van der Kouwe, Andre J. W.& Davies, Neil H.…[et al.]. 2012. Long-Term Left Ventricular Remodelling in Rat Model of Nonreperfused Myocardial Infarction : Sequential MR Imaging Using a 3T Clinical Scanner. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-476838
Modern Language Association (MLA)
Saleh, Muhammad G.…[et al.]. Long-Term Left Ventricular Remodelling in Rat Model of Nonreperfused Myocardial Infarction : Sequential MR Imaging Using a 3T Clinical Scanner. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-476838
American Medical Association (AMA)
Saleh, Muhammad G.& Sharp, Sarah-Kate& Alhamud, Alkathafi& Spottiswoode, Bruce S.& van der Kouwe, Andre J. W.& Davies, Neil H.…[et al.]. Long-Term Left Ventricular Remodelling in Rat Model of Nonreperfused Myocardial Infarction : Sequential MR Imaging Using a 3T Clinical Scanner. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-476838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476838