Immunomodulation in Sepsis : The Role of Endotoxin Removal by Polymyxin B-Immobilized Cartridge
Joint Authors
Artigas, Antonio
Esteban, Elisabeth
Alsina, Laia
Ferrer, Ricard
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Severe sepsis results in high morbidity and mortality.
Immunomodulation strategies could be an adjunctive therapy to treat sepsis.
Endotoxin is a component of gram-negative bacteria and plays an important role in the pathogenesis of septic shock when it is recognized by immune cells.
Removal of endotoxin could be an effective adjunctive approach to the management of sepsis.
Devices to adsorb endotoxin or inflammatory cytokines have been designed as a strategy to treat severe sepsis, especially sepsis caused by gram-negative bacteria.
Polymyxin B-immobilized cartridge has been successfully used to treat patients with sepsis of abdominal origin.
Although this cartridge was conceived to adsorb endotoxin, several other immunological mechanisms have been elucidated, and this device has also yielded promising results in patients with nonseptic respiratory failure.
In this paper, we summarize the immune modulation actions of Polymyxin B-immobilized cartridge to explore its potential usefulness beyond endotoxin elimination.
American Psychological Association (APA)
Esteban, Elisabeth& Ferrer, Ricard& Alsina, Laia& Artigas, Antonio. 2013. Immunomodulation in Sepsis : The Role of Endotoxin Removal by Polymyxin B-Immobilized Cartridge. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-477160
Modern Language Association (MLA)
Esteban, Elisabeth…[et al.]. Immunomodulation in Sepsis : The Role of Endotoxin Removal by Polymyxin B-Immobilized Cartridge. Mediators of Inflammation No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-477160
American Medical Association (AMA)
Esteban, Elisabeth& Ferrer, Ricard& Alsina, Laia& Artigas, Antonio. Immunomodulation in Sepsis : The Role of Endotoxin Removal by Polymyxin B-Immobilized Cartridge. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-477160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477160