Immunomodulation in Sepsis : The Role of Endotoxin Removal by Polymyxin B-Immobilized Cartridge

Joint Authors

Artigas, Antonio
Esteban, Elisabeth
Alsina, Laia
Ferrer, Ricard

Source

Mediators of Inflammation

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-10-22

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Diseases

Abstract EN

Severe sepsis results in high morbidity and mortality.

Immunomodulation strategies could be an adjunctive therapy to treat sepsis.

Endotoxin is a component of gram-negative bacteria and plays an important role in the pathogenesis of septic shock when it is recognized by immune cells.

Removal of endotoxin could be an effective adjunctive approach to the management of sepsis.

Devices to adsorb endotoxin or inflammatory cytokines have been designed as a strategy to treat severe sepsis, especially sepsis caused by gram-negative bacteria.

Polymyxin B-immobilized cartridge has been successfully used to treat patients with sepsis of abdominal origin.

Although this cartridge was conceived to adsorb endotoxin, several other immunological mechanisms have been elucidated, and this device has also yielded promising results in patients with nonseptic respiratory failure.

In this paper, we summarize the immune modulation actions of Polymyxin B-immobilized cartridge to explore its potential usefulness beyond endotoxin elimination.

American Psychological Association (APA)

Esteban, Elisabeth& Ferrer, Ricard& Alsina, Laia& Artigas, Antonio. 2013. Immunomodulation in Sepsis : The Role of Endotoxin Removal by Polymyxin B-Immobilized Cartridge. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-477160

Modern Language Association (MLA)

Esteban, Elisabeth…[et al.]. Immunomodulation in Sepsis : The Role of Endotoxin Removal by Polymyxin B-Immobilized Cartridge. Mediators of Inflammation No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-477160

American Medical Association (AMA)

Esteban, Elisabeth& Ferrer, Ricard& Alsina, Laia& Artigas, Antonio. Immunomodulation in Sepsis : The Role of Endotoxin Removal by Polymyxin B-Immobilized Cartridge. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-477160

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-477160