High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice : A Protective Role for PPAR-δ Agonism

Joint Authors

Collino, Massimo
Fantozzi, Roberto
Rogazzo, Mara
Minetto, Marco Alessandro
Benetti, Elisa
Mastrocola, Raffaella
Chiazza, Fausto
Aragno, Manuela

Source

Mediators of Inflammation

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-06-18

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Diseases

Abstract EN

Peroxisome Proliferator Activated Receptor (PPAR)-δ agonists may serve for treating metabolic diseases.

However, the effects of PPAR-δ agonism within the skeletal muscle, which plays a key role in whole-body glucose metabolism, remain unclear.

This study aimed to investigate the signaling pathways activated in the gastrocnemius muscle by chronic administration of the selective PPAR-δ agonist, GW0742 (1 mg/kg/day for 16 weeks), in male C57Bl6/J mice treated for 30 weeks with high-fructose corn syrup (HFCS), the major sweetener in foods and soft-drinks (15% wt/vol in drinking water).

Mice fed with the HFCS diet exhibited hyperlipidemia, hyperinsulinemia, hyperleptinemia, and hypoadiponectinemia.

In the gastrocnemius muscle, HFCS impaired insulin and AMP-activated protein kinase signaling pathways and reduced GLUT-4 and GLUT-5 expression and membrane translocation.

GW0742 administration induced PPAR-δ upregulation and improvement in glucose and lipid metabolism.

Diet-induced activation of nuclear factor-κB and expression of inducible-nitric-oxide-synthase and intercellular-adhesion-molecule-1 were attenuated by drug treatment.

These effects were accompanied by reduction in the serum concentration of interleukin-6 and increase in muscular expression of fibroblast growth factor-21.

Overall, here we show that PPAR-δ activation protects the skeletal muscle against the metabolic abnormalities caused by chronic HFCS exposure by affecting multiple levels of the insulin and inflammatory cascades.

American Psychological Association (APA)

Benetti, Elisa& Mastrocola, Raffaella& Rogazzo, Mara& Chiazza, Fausto& Aragno, Manuela& Fantozzi, Roberto…[et al.]. 2013. High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice : A Protective Role for PPAR-δ Agonism. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-477325

Modern Language Association (MLA)

Benetti, Elisa…[et al.]. High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice : A Protective Role for PPAR-δ Agonism. Mediators of Inflammation No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-477325

American Medical Association (AMA)

Benetti, Elisa& Mastrocola, Raffaella& Rogazzo, Mara& Chiazza, Fausto& Aragno, Manuela& Fantozzi, Roberto…[et al.]. High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice : A Protective Role for PPAR-δ Agonism. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-477325

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-477325