High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice : A Protective Role for PPAR-δ Agonism
Joint Authors
Collino, Massimo
Fantozzi, Roberto
Rogazzo, Mara
Minetto, Marco Alessandro
Benetti, Elisa
Mastrocola, Raffaella
Chiazza, Fausto
Aragno, Manuela
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Peroxisome Proliferator Activated Receptor (PPAR)-δ agonists may serve for treating metabolic diseases.
However, the effects of PPAR-δ agonism within the skeletal muscle, which plays a key role in whole-body glucose metabolism, remain unclear.
This study aimed to investigate the signaling pathways activated in the gastrocnemius muscle by chronic administration of the selective PPAR-δ agonist, GW0742 (1 mg/kg/day for 16 weeks), in male C57Bl6/J mice treated for 30 weeks with high-fructose corn syrup (HFCS), the major sweetener in foods and soft-drinks (15% wt/vol in drinking water).
Mice fed with the HFCS diet exhibited hyperlipidemia, hyperinsulinemia, hyperleptinemia, and hypoadiponectinemia.
In the gastrocnemius muscle, HFCS impaired insulin and AMP-activated protein kinase signaling pathways and reduced GLUT-4 and GLUT-5 expression and membrane translocation.
GW0742 administration induced PPAR-δ upregulation and improvement in glucose and lipid metabolism.
Diet-induced activation of nuclear factor-κB and expression of inducible-nitric-oxide-synthase and intercellular-adhesion-molecule-1 were attenuated by drug treatment.
These effects were accompanied by reduction in the serum concentration of interleukin-6 and increase in muscular expression of fibroblast growth factor-21.
Overall, here we show that PPAR-δ activation protects the skeletal muscle against the metabolic abnormalities caused by chronic HFCS exposure by affecting multiple levels of the insulin and inflammatory cascades.
American Psychological Association (APA)
Benetti, Elisa& Mastrocola, Raffaella& Rogazzo, Mara& Chiazza, Fausto& Aragno, Manuela& Fantozzi, Roberto…[et al.]. 2013. High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice : A Protective Role for PPAR-δ Agonism. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-477325
Modern Language Association (MLA)
Benetti, Elisa…[et al.]. High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice : A Protective Role for PPAR-δ Agonism. Mediators of Inflammation No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-477325
American Medical Association (AMA)
Benetti, Elisa& Mastrocola, Raffaella& Rogazzo, Mara& Chiazza, Fausto& Aragno, Manuela& Fantozzi, Roberto…[et al.]. High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice : A Protective Role for PPAR-δ Agonism. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-477325
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477325